The first synthesis of hydroxamic acids from alcohols has been developed. Both benzylic and aliphatic alcohols can be tolerated and applied in this reaction. The methodology is economical, environmentally benign and high yielding.

the effect of alkyl substituents on the c-phenyl and/or the n-phenyl ring of benzophenylhydroxamic acid on their molecular structure and hydrogen bonding has been investigated. the predominant configuration in chcl3 is determined by steric and electronic effects. substituents on the c-phenyl ring favor the cis configuration, while substituents in the n-phenyl ring favor a trans configuration. t...

Simple hydroxamic acids (XHA) are hydrophilic organic compoundswith the general formula RCONHOH that can act as O,O donor ligands with high affinities for hard cations such as Fe3+, Np4+ and Pu4+ with which they form 5-membered chelate rings (Muri et al.,2002; Desaraju & Winston,1986; Carrott et al.,2007). They have a wide range of applications in many fields, including as enzyme inhibitors, so...

Histone deacetylase inhibitors (HDACi) target abnormal epigenetic states associated with a variety of pathologies, including cancer. Here, the development of a prodrug of the canonical broad-spectrum HDACi suberoylanilide hydroxamic acid (SAHA) is described. Although hydroxamic acids are utilized universally in the development of metalloenzyme inhibitors, they are considered to be poor pharmaco...

LpxC inhibitors represent a promising class of novel antibiotics selectively combating Gram-negative bacteria. In chiral pool syntheses starting from D- and L-xylose, series four 2r,3c,4t-configured C-furanosidic was obtained. The synthesized hydroxamic acids were tested for antibacterial inhibitory activity, the acquired biological data compared with those previously C-furanosides, molecular d...