A new, simple, accurate, and precise high-performance thin-layer chromatographic (HPTLC) method has been established for simultaneous analysis of valsartan and hydrochlorothiazide in tablet formulations. Standard and sample solutions of valsartan and hydrochlorothiazide were applied to precoated silica gel G 60 F254 HPTLC plates and the plates were developed with chloroform–ethyl acetate–acetic...

In the present work for the determination of Olmesartan Medoxomil, Hydrochlorothiazide and Amlodipine a simple, rapid and precise high performance liquid chromatography procedure has been developed and validated. The separation and quantification were achieved on a Cyano C18 column using a mobile phase of filtered and degassed mixture of buffer and acetonitrile in the ratio of 830:170 with of a...

A simultaneous determination of olmesartan medoxomil and hydrochlorothiazide by absorption ratio spectrophotometric method has been developed in combined tablet dosage form. The method is based on measurements of absorbance at isoabsoptive point. The Beer's law obeys in the range of 10-30 mug/ml for both olmesartan medoxomil and hydrochlorothiazide respectively. The proposed method was validate...

INTORDUCTION Methyldopa is (2S)-2-amino-3-(3, 4dihydroxyphenyl)-2-methylpropanoic acid (figure1a). Hydrochlorothiazide is 6-chloro-1, 1-dioxo-3,4dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide (figure1b). Methyldopa and Hydrochlorothiazide are official in Indian Pharmacopoeia and U.S. Pharmacopoeia, but there is no official method for the combination. Both drugs in combination of tablet dosage ...

BACKGROUND The treatment of central diabetes insipidus (DI) with desmopressin in the neonatal period is challenging because of the significant risk of hyponatremia with this agent. The fixed anti-diuresis action of desmopressin and the obligate high fluid intake with milk feeds lead to considerable risk of water intoxication and hyponatremia. To reduce this risk, thiazide diuretics, part of the...

The combination of an angiotensin II type 1 receptor blocker (valsartan) and a thiazide diuretic (hydrochlorothiazide) has been evaluated in the treatment of patients with hypertension in several clinical trials. The valsartan/hydrochlorothiazide (VAL-HCT) combination was found to be generally more effective than either drug given alone. The incidence of adverse events in VAL-HCT recipients was...

BACKGROUND Potassium depletion by thiazide diuretics is associated with a rise in blood glucose. We assessed whether addition or substitution of a potassium-sparing diuretic, amiloride, to treatment with a thiazide can prevent glucose intolerance and improve blood pressure control. METHODS We did a parallel-group, randomised, double-blind trial in 11 secondary and two primary care sites in th...

Two methods for the simultaneous estimation of atenolol and hydrochlorothiazide in combined tablet dosage form have been developed. The first method is the Q-analysis method, based on absorbance ratio at two selected wave lengths 232.0nm (Iso-absorptive point) and 270.0nm (λmax of hydrochlorothiazide). The second method is the first order derivative spectroscopy using 214.0nm (zero cross for at...

patients and methods this study was a randomized double-blind placebo-controlled clinical trial. a hundred boys with pmne and ihc were randomly assigned into two groups of experimental (treated with hct 1 mg/kg/day) and control and all patients were followed for 4 months for the number of wet-night episodes. results the mean numbers of wet-night episodes in the first (intervention: 8.34 ± 8.54,...