Engineered cocrystals offer an alternative solid drug form with tailored physicochemical properties. Interestingly, although cocrystals provide many new possibilities, they also present new challenges, particularly in regard to their design and large-scale manufacture. Current literature has primarily focused on the preparation and characterization of novel cocrystals typically containing only ...

Measurement of the high-temperature melt pool region in the laser powder bed fusion (L-PBF) process is a primary focus of researchers to further understand the dynamic physics of the heating, melting, adhesion, and cooling which define this commercially popular additive manufacturing process. This paper will detail the design, execution, and results of high speed, high magnification in-situ the...

In the past two decades, the repair and reconstruction of musculoskeletal tissues using biodegradable scaffold materials has emerged as one of the most promising approaches in tissue engineering. The aim of this study is to process, via hot melt extrusion, the biodegradable and biocompatible polymeric materials; poly(ethylene oxide) (PEO), poly(ethylene glycol) (PEG), ⍺lactose monohydrate and p...

A two part study utilizing isotactic poly(4 -methyl-1-pentene) (PMP) was undertaken to investigate a three stage process (melt-extrusion/annealing/uniaxial-stretching) (MEAUS) to produce microporous films. In this report, the thermal annealing (second stage) and subsequent uniaxial-stretching (third stage) results of selected PMP films from three resins, labeled A, B & C, are discussed. From se...

A novel multicollision induced dissociation scheme is employed to determine the energy content for mass-selected gallium cluster ions as a function of their temperature. Measurements were performed for Ga(+)(n) (n=17 39, and 40) over a 90-720 K temperature range. For Ga+39 and Ga+40 a broad maximum in the heat capacity-a signature of a melting transition for a small cluster-occurs at around 550...

The present study aimed to evaluate the effect of degassing on an extrusion process, with respect to extrudate quality and drug release properties. Processed formulations were extruded with and without a degassing vent port at various locations along the barrel. All the experiments were performed under constant processing temperature, feeding rate, and screw speed. During the extrusion process,...

Hot-melt extrusion is commonly applied for forming products, ranging from metals to plastics, rubber and clay composites. It is also increasingly used for the production of pharmaceuticals, such as granules, pellets and tablets. In this context, mathematical modeling plays an important role to determine the best process operating conditions, but also to possibly develop software sensors or cont...

Department of Pharmaceutical Technology, Meerut Institute of Engineering & Technology, NH-58, Baghpat Road-Bypass Crossing, Meerut-250005 (U.P), India ABSTRACT Drug release from mucoadhesive patches at predetermined rate in oral cavity having distinct advantages over traditional dosage forms as tablets, gels and solutions. This review provides brief information about method of preparation and e...