OBJECTIVES The aim was to evaluate the effect of high molecular weight protein fraction of Calotropis procera latex on edema formation and oxidative stress in carrageenan-induced paw inflammation. METHODS A sub-plantar injection of carrageenan was given to induce edema in the hind paw of the rat. The inhibitory effect of high molecular weight protein fraction of C. procera latex was evaluated...

To determine the pharmacological (Anti-inflammatory) potential of in-vitro cultures of Asparagus racemosus. Anti-inflammatory activity of methanolic extracts of shoot, root their calli and genetically transformed shoot culture was performed using carrageenan induced rat paw edema method. The albino rats were treated orally with two dosage (500 or 1000 mg/kg body weight of rats) of drugs, one ho...

BACKGROUND Studies show that electroacupuncture (EA) has beneficial effects in patients with inflammatory diseases. This study investigated the mechanisms of EA anti-inflammation, using a rat model of complete Freund's adjuvant (CFA)-induced hind paw inflammation and hyperalgesia. DESIGN Four experiments were conducted on male Sprague-Dawley rats (n = 6-7/per group). Inflammation was induced ...

Ischemic preconditioning (IPC), a strategy used to attenuate ischemia-reperfusion injury, consists of brief ischemic periods, each followed by reperfusion, prior to a sustained ischemic insult. The purpose of the present study was to evaluate the local and systemic anti-inflammatory effects of hind limb IPC in male Wistar rat (200-250 g) models of acute inflammation. IPC was induced with right ...

The anti-inflammatory and analgesic activity of various extracts of Ficus glomerata Roxb. were evaluated in experimental animals. We have determined the anti-inflammatory and analgesic activity of various extracts of the dried fruits of Ficus glomerata by oral administration at doses of 200 and 400 mg/kg of body weight to healthy animals. The extracts were studied for their anti-inflammatory ac...

Adjuvant arthritis (AA) is a model of chronic inflammation induced by Mycobacterium butyricum and characterized by similar pathophysiological and pathobiochemical changes as rheumatoid arthritis (RA) in humans. In this study the antirheumatic activity of coenzyme Q(10) supplementation was tested not only as to its capability to suppress the inflammation edema of the hind paw and to improve the ...

Objective: Vitex negundo, commonly known as “nirgundi” is widely used in traditional as well as in folk medicines to cure many ailments such as fever, rheumatism, gum and skin diseases and liver disorders, etc. The present study evaluated the antioxidant potency of hydroethanolic extract of Vitex negundo leaves (VNE) in Freund’s complete adjuvant (FCA) induced arthritis. Methods: Acute oral tox...

Smilax canariensis Brouss. ex Willd. is an endemic plant of the Canary Islands. Its rhizomes, leaves and stems have been traditionally used in Canary folk medicine to treat a wide variety of conditions including pain. Our objective is to investigate the analgesic and anti-inflammatory activities of different extracts of S. canariensis in Swiss mice, using established biological models for pain ...

OBJECTIVE To assess the effect of high-voltage cathodic current on pain from a sciatica experimental model. METHODS A total of 16 male Wistar rats were submitted to the sciatica experimental model in the right hind paw. They were divided into sham group (GS) and group treated with cathodic current (GP-) for 20 min/daily, for 10 days). The model of sciatic compression was performed with a 4.0-...

Background: Inflammation is a normal protective response to tissue injury caused by physical trauma, chemicals, or microbiological substances. The manifestation clinic of inflammation pain. Miana leaves (Coleus atropurpureus Benth.) have chemical contents such as essential oils, phenols, flavonoids, and polyphenols. Flavonoids can protect lipid membranes from damage inhibit cyclooxygenase, whic...