present series of cases of peritonitis complicating acute appendicitis. The available biochemical evidence points to an obstructive pattern of jaundice without signs of extrahepatic block. This indicates that the jaundice is of the cholestatic type: and, as suggested by Eley et al. (1965), this is possibly a hepatotoxic effect of the infecting organism, which was E. coli in most of the previous...

To determine the hepatotoxic effect of halothane anaesthesia, liver function tests were done a day prior to surgery in 41 cases undergoing various elective operations. The tests were repeated on 7th post operative day to see the derangement. Statistically significant rise in serum bilirubin, ALT and alkaline phosphatase was found post-operatively. As certain groups of patients are more prone to...

For over a century clinicians and pathologists have recognized a relationship between over-indulgence in alcohol and the occurrence of cirrhosis, but attempts to demonstrate a direct hepatotoxic effect of ethyl alcohol or to produce alcoholic cirrhosis experimentally in animals have generally been unsuccessful. Moreover, as the result of recent studies on the hepatic effects of dietary deficien...

In the group of chemical hepatocarcinogenic agents, the number of which has steadily increased in recent years (:$7), tannic acid deserves attention. Owing to its astringent effect, this compound was formerly used widely in therapy. The local treatment of thermal burns with tannic acid was suggested by Davidson (1935), and his procedure was generally employed in Hungary during World War II. I t...