Background: Mentha longifolia is one of the aromatic medicinal plant belongs to Lamiaceae family. There are some active ingredients in the essential oil of M. longifolia, which potentially could impair the hepatic function. The aim of this study was to find the maximum dose of essential oil of M. longifolia (EOML) that does not show any hepatic deterioration. Methods: Adult Wistar rats fed d...

Section 4, 4th paragraph, 1st sentence, which previously read: The lower sunitinib hepatic exposure in female mice may anticipate both, the lesser susceptibility to toxicity observed of male patients [32], and the higher incidence (p = 0.016) of C3 grade adverse events [14, 15] and risk (p = 0.04) of thrombocytopenia [16] in female patients. Should read: The lower sunitinib hepatic exposure in ...

Methotrexate has been used successfully for the treatment of psoriasis since 1951, and over the past decade its use has increased significantly in the treatment of psoriatic arthritis and rheumatoid arthritis. The potential for hepatic toxicity remains a concern to physicians who are increasingly using this drug. The American Association of Dermatology has specific guidelines for monitoring the...

Background and objectives: The present work aimed to evaluate the acute toxicity of Aeollanthus pubescens essential oil, whose antimicrobial activity has been proven in vitro by previous studies and to examine the effects of this essential oil on the biochemical parameters (transaminases ALT and AST, urea, creatinine and cholesterol) and hematological and histological ...

ammonia is the chief excretory product in fishes. however, non-availability of enough of water in the habitat, may lead to the formation of urea, in fishes. in the present study, the possible role of urea formation to avoid the toxicity of ammonia under water-restricted condition was tested in channa gachua. circulatory urea and ammonia were estimated in the blood of the fishes and glutamate de...

OBJECTIVES The aim of this study was to evaluate the toxicity of a new lipid complex formulation of amphotericin B (LC-AmB) produced by a simple process. METHODS Toxicity was evaluated after daily administration for 21 consecutive days in female CD1 mice. Doses of LC-AmB up to 20 mg/kg were used, and compared with Fungizone at 0.5 mg/kg and Abelcet at 10 mg/kg. Acute toxicity after a single b...

background: mentha longifolia is one of the aromatic medicinal plant belongs to lamiaceae family. there are some active ingredients in the essential oil of m. longifolia, which potentially could impair the hepatic function. the aim of this study was to find the maximum dose of essential oil of m. longifolia (eoml) that does not show any hepatic deterioration. methods: adult wistar rats fed diff...

One major challenge with the use of anticancer agents is the phenomenon of drug-induced toxicity. Melphalan (MPLN) is an alkylating anticancer agent, while quercetin (QCT) is an antioxidant. We investigated the protective role of quercetin against MPLN-induced toxicity. Twenty-five male Wistar rats (160-170 g) were randomized into five treatment groups; (I) control, (II) MPLN (0.2 mg/kg b.w.), ...

Aim: To study the comparative hepatoprotective effect of Virgin Coconut Oil (VCO) and Neem (Azadirachta indica) leaf extract in acetaminophen (Paracetamol) induced liver toxicity. Methods: About 60 mixed population rats (male/female) Wistar Sprague-Dawley species were randomly selected for proposed are segregated into four equal groups. Every group contains 15 animal subjects. Group A was contr...

Herbal medication has gathered increasing recognition in recent years with regard to both treatment options and health hazards. Pyrrolizidine alkaloids have been associated with substantial toxicity after their ingestion as tea and in the setting of contaminated cereals have led to endemic outbreaks in Jamaica, India and Afghanistan. In Western Europe, comfrey has been applied for inflammatory ...