The synthetic antioxidant ethoxyquin (EQ) is increasingly used in animal feeds and has been candidate for carcinogenicity testing. EQ has the potential for toxicological and adverse health effects for both fish and fish consumers through "carryover" processes. The toxicological aspects of EQ have not been systematically investigated. The present study was performed to investigate the hepatic me...

the present investigation aims at assessing the hepatoprotective effect of triterpene fraction isolated from the stem bark of wrightia tinctoria (containing lupeol, b -amyrin and b -sitosterol) on ccl 4 -induced hepatotoxicity in the rat. ccl 4 (1.5 mg/kg, i.p) is a potent hepatotoxic agent which causes peroxidative degeneration of membrane lipids with the potential outcome of fatty degeneratio...

The present study clearly showed that chronic exposure to polychlorinated biphenyls (PCBs) at environmentally relevant concentrations can damage juvenile tilapia livers by modulating antioxidant enzyme activities and gene transcription, which affects toxic bioaccumulation and histological congestion. The results suggest that PCBs caused a decrease in the activity of some hepatic antioxidative a...

The characterization of fully-defined in vitro hepatic culture systems requires testing of functional and morphological variables to obtain the optimal trophic support, particularly for cell therapeutics including bioartificial liver systems (BALs). Using serum-free fully-defined culture medium formulations, we measured synthetic, detoxification and metabolic variables of primary porcine hepato...

the present investigation was aimed at studying the effect of incubation period, media, vitamins and solvents on biotransformation of albendazole by cunninghamella blakesleeana. the transformation was evaluated and identified by high performance liquid chromatography (hplc) and the structures of the transformed products were assigned by liquid chromatography-tandem mass spectrometry (lc/ms/ms) ...

Background Hepatic steatosis refers to the accumulation of triglycerides in hepatocytes, and it can be attributed to excessive ethanol consumption. The liver is the main organ of ethanol biotransformation and therefore, it can suffer with oxidative stress generated by ethanol. Since the FXR agonist 6ECDCA regulates adipose cell function, the aim of this work is to evaluate the participation of ...