Serum haptoglobins have been found to be useful genetic markers. The distribution of the different haptoglobin genes was found to vary in different parts of the world (Giblett, I96I). Thus Orientals and Eskimos were found to have a high incidence of the gene Hp2 and Negroes a high incidence of Hp'. Caucasians in continental Europe, Australia, and the United States have revealed an intermediate ...

Variations in the human karyotype have been found in association with a variety of congenital anomalies and also in the normal population (Miller and Mukherjee, 1962; Court Brown, 1967). Court Brown's population studies (1967) have revealed that between 2 and 3%o of the normal adult population has a karyotype with structural autosomal variations. Occasionally, homologous autosomes reveal differ...

The human leukocyte nuclear histones can bind to haptoglobin (Hp), and thus interfere with subsequent binding of Hb. The Hp/Hb complex possesses peroxidase activity, but a Hp/histone complex does not. The inhibitory effect of histone molecules depends directly on the Hp and Hb, as well as the histone concentrations. The biological significance of the complex Hp/Hb as a measure of intravascular ...

Nitrogranulogen (NTG) may modify the character of inflammatory reactions. These modifications are a result of cytotoxic and mutagenic effects. NTG has high affinity to DNA and causes disorders in the synthesis of acute phase proteins (e.g., haptoglobin, transferrin, fibrinogen, and complement protein C3). Our previous studies have shown that small doses of NTG can enhance immunological defense ...

The relation between serum inflammatory protein levels and cognitive performance was investigated in a healthy population. Individuals were tested during 6 years of follow-up. Serum concentrations of 10 inflammatory proteins were correlated to cognitive speed (Letter-Digit Coding Test, LDCT), attention and information processing (Stroop) and memory (Word Learning). Haptoglobin levels at baselin...

Serum amyloid A (SAA) and haptoglobin (Hp) levels were determined in 25 cows suffering from amyloidosis. SAA levels in cows with amyloidosis ranged between < 0.3 and 225.8 microg/ml, with a median level of 105.1 microg/ml, and Hp levels ranged between < 20 and 1860 microg/ml, with a median level of 950 microg/ml. These levels were significantly higher than the levels observed in healthy cows (S...

A study of 12 immunologically distinct serum proteins has been made in two conditions, tuberculosis and sarcoidosis, which have in common the formation of giant-cell granulomata. Significantly (P<0001) higher concentrations of five proteins [I2 group component (GC), caeruloplasmin (caer), haptoglobin (hpt), haemopexin (hpx), and a, easily precipitable glycoprotein (a, PGp)] were found in tuberc...

This study was designed to investigate the alteration in serum haptoglobin (Hp) concentration in dystocia affected cows in comparison to those having normal parturition. Thirty cows included in this study, seventeen with normal parturition and thirteen with difficult parturition (dystocia). Blood samples, from cows that having normal parturition, were collected every three days during the last ...

Human hemoglobin (aNOD), in which a! chains were liganded with nitric oxide and p chains were unliganded, showed a characteristic spectrum in the Soret region. Its absorption was significantly reduced compared with the averaged absorption of IX-NO and p. On the other hand, a complex of (cuNO0) with haptoglobin did not show such a characteristic spectrum. It was concluded, therefore, that there ...

Segregated early-weaned pigs (initially 4.0 kg and 14 +/- 1.5 d of age) were used to quantify the effects of lipopolysaccharide (LPS)-induced immune challenge and nursery diet complexity (complex, medium, and simple) on growth performance and haptoglobin production. Three treatments of immune challenge consisted of pigs given ad libitum access to feed (control), challenged with LPS and given ad...