نتایج جستجو برای: haplotype analysis

تعداد نتایج: 2832840  

Journal: :Genetic epidemiology 2006
Nianjun Liu Isabel Beerman Richard Lifton Hongyu Zhao

It is common to have missing genotypes in practical genetic studies, but the exact underlying missing data mechanism is generally unknown to the investigators. Although some statistical methods can handle missing data, they usually assume that genotypes are missing at random, that is, at a given marker, different genotypes and different alleles are missing with the same probability. These inclu...

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Journal: :Journal of Archaeological Science: Reports 2021

• Lynx bones were found at Castellum Albaniana in the Netherlands. Q-PCR and sequencing identified lynx mitochondrial DNA sequences. haplotype was not identical to ancient remains matched with a Southern European haplotype. In 2001 2002 an excavation conducted town of Alphen aan den Rijn Netherlands revealed vestiges Roman fort, , situated along historical Rhine delta used for centuries during ...

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2011
Yungang He Cong Li Christopher I. Amos Momiao Xiong Hua Ling Li Jin

The genome-wide association study (GWAS) has become a routine approach for mapping disease risk loci with the advent of large-scale genotyping technologies. Multi-allelic haplotype markers can provide superior power compared with single-SNP markers in mapping disease loci. However, the application of haplotype-based analysis to GWAS is usually bottlenecked by prohibitive time cost for haplotype...

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Journal: :American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2006
Sepideh N Bajestan Amir H Sabouri Masayuki Nakamura Hiroshi Takashima Mohammad R Keikhaee Fatemeh Behdani Mohammad R Fayyazi Mohammad R Sargolzaee Mahboobeh N Bajestan Zahra Sabouri Esmaeil Khayami Sima Haghighi Susan B Hashemi Nobutaka Eiraku Hamid Tufani Hossein Najmabadi Kimiyoshi Arimura Akira Sano Mitsuhiro Osame

AKT-glycogen synthase kinase 3beta (GSK3beta) signaling is a target of lithium and has been implicated in the pathogenesis of mood disorders and schizophrenia. AKT1 protein level is decreased in the peripheral lymphocytes and brains of schizophrenic patients. The SNP2/3/4 TCG haplotype of AKT1 was associated with schizophrenia in patients with Northern European origin. In the present study, we ...

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2014
Xiaowei Shen Osvaldo Espin-Garcia Xin Qiu Yonathan Brhane Geoffrey Liu Wei Xu

We applied a gene-based haplotype approach for the genome-wide association analysis on hypertension using Genetic Analysis Workshop 18 data for unrelated individuals. Association of single-nucleotide polymorphisms and clinical outcome were first assessed and haplotypes were then constructed based on the gene information and the linkage disequilibrium plot. Extensive haplotype analysis was also ...

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2006
Tom Nichols

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Journal: :Bioinformatics 2002
Jing Hua Zhao Sebastien Lissarrague Laurent Essioux Pak Chung Sham

A general algorithm is described for haplotype analysis of unrelated individuals with missing genotypes. It can handle problems involving multiple polymorphic markers with missing data.

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Journal: :Genetic epidemiology 2007
Zhaoxia Yu Daniel J Schaid

Multi-locus association analyses, including haplotype-based analyses, can sometimes provide greater power than single-locus analyses for detecting disease susceptibility loci. This potential gain, however, can be compromised by the large number of degrees of freedom caused by irrelevant markers. Exhaustive search for the optimal set of markers might be possible for a small number of markers, ye...

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Journal: :BMC Genetics 2010

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Journal: :Bioinformatics 2001
Louxin Zhang Chew-Kiat Heng Tin Wee Tan

SUMMARY We implement a program that incorporates polymorphic sites data, haplotype frequency arrays, and other factors, into cladogram estimation.

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