Background/Aim: Cervical cancer (CC) is the most common gynecological malignancy in women. In spite of a variety treatment protocols, it necessary to carefully investigate all factors that play role pathogenesis these tumors which may have mortal progression. this context, our study we aimed assess myeloperoxidase (MPO) gene polymorphism, an important inflammatory enzyme, among cervix cases. Me...

Although the immobilization of oligonucleotides (nucleic acid) on mineral surfaces is at basis different biotechnological applications, an atomistic understanding interaction nucleic acid components with titanium dioxide has not yet been achieved. Here, adsorption phosphate anion, four DNA bases (adenine, guanine, thymine, and cytosine) some entire nucleotides dinucleotides TiO2 anatase (1 0 1)...

The thermodynamics and kinetics for the monofunctional binding of the antitumor drug cisplatin, cis-diamminedichloroplatinum(II), to a purine base site of DNA were studied computationally using guanine and adenine as model reactants. A dominating preference for initial attack at the N7-position of guanine is established experimentally, which is a crucial first step for the formation of a 1,2-in...

The importance of the depletion of guanine nucleotides in cellular toxicity was compared to that of the depletion of adenine nucleotides following the inhibition of early de novo purine bio synthesis in the mouse T lymphoma (S-49) cell line. Early de novo purine biosynthesis was blocked with 6-methylmercaptopurine ribonucleoside (6MMPR), while adenine and guanine nucleotide biosyntheses were in...