We investigated the effect of curcumin on insulin resistance and glucose homeostasis in male C57BL/KsJ-db/db mice and their age-matched lean non-diabetic db/+ mice. Both db/+ and db/db mice were fed with or without curcumin (0.02%, wt/wt) for 6 wks. Curcumin significantly lowered blood glucose and HbA 1c levels, and it suppressed body weight loss in db/db mice. Curcumin improved homeostasis mod...

BACKGROUND Chronic kidney disease (CKD), a condition frequently attributed to uncontrolled diabetes and hypertension, has become an economic and public health burden both globally and locally. The present study was designed to investigate the toxic effects of lead and hypertension (HTN) on chronic renal failure (CRF). METHOD It was a cross-sectional, prospective study conducted in Jinnah Post...

Preliminary research on activated sludge potassium efflux (GGKE – glutathione-gated potassium efflux) as a result of peroxyacetic acid (PAA) dosing were performed. Similar to the case of chlorine dosing, the PAA dosing causes initiation of bacteria defense mechanisms related to the transformations of gluthathione tripeptide, resulting in the increase of potassium ion concentrations in the activ...

AIM To test the early effect of fructose-induced changes in fatty acid composition and oxidative stress markers in perivascular adipose tissue (PVAT) upon vascular contractility. METHODS Adult male Wistar rats were fed a commercial diet without (CD) or with 10% fructose (FRD) in the drinking water for 3 weeks. We measured plasma metabolic parameters, lipid composition and oxidative stress mar...

This study documents effects of the toxic dinoflagellate Gymnodinium catenatum, a producer of paralytic shellfish poison, on juvenile farmed (5.9+/-0.39 cm) giant lions-paw scallop Nodipecten subnodosus. Scallops were fed bloom concentrations of toxic dinoflagellate G. catenatum for 7 h. The effect of the toxic dinoflagellate in different tissues was determined by analysis of antioxidant enzyme...

To evaluate the level of glutathione (GSH) and gluthathione peroxidase (GSH-Px) activity in the anterior ule of patients with cataract in diabetic patients with meticulous control and in patients with senile cataract. The anterior lens capsules in 18 eyes with diabetes under tight glycemic control with cataract (Group A) 6 eyes with senile cataract (Group B) were collected in phacoemulsificatio...

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