Epilepsy was induced by making freeze lesions bilaterally in the mesencephalic reticular formation of cats. The convulsive activity was an equivalent of the generalized status epilepticus, devaloping 15-20 min after the freeze lesions had been made. The animals died in this state 16-20 h after it had developed. The generalized seizure activity may have spread to rostra1 structures from the lesi...

BACKGROUND Various anticonvulsant medications have been associated with paradoxical aggravation of epileptic seizures in therapeutic doses and toxic concentrations. Lamotrigine has been reported to exacerbate seizures and myoclonic seizures in generalized epilepsy in a child with localization-related epilepsy. OBJECTIVE To describe lamotrigine intoxication paradoxically producing status epile...

We report a patient who was referred to our department because of generalized status epilepticus. His condition deteriorated rapidly and he died 1 month after admission. Autopsy confirmed the clinical diagnosis of Creutzfeldt-Jakob disease (CJD). CJD should be added to the list of rare but possible causes of generalized status epilepticus.

Status epilepticus (SE) is defined as a seizure lasting longer than 5 min, or at least two seizures without full recovery of consciousness between them. Early emergent medical management consists of life support and an etiology survey, and subsequent treatment can be classified into 4 stages: (1) early SE, (2) established SE, (3) refractory SE, and (4) super-refractory SE. For early SE, benzodi...

PURPOSE Convulsive status epilepticus (CSE) is a common neurologic emergency in elderly people. The current study elaborates the clinical characteristics and outcome of CSE in elderly patients. METHODS Analysis of data of generalized CSE patients, aged 60 years and above admitted at the neurointensive care unit (NICU) was performed. The primary outcome for analysis was in-hospital mortality. ...

The epileptic semiology of 19 patients (from 15 families) with mitochondrial disease due to mutations in the POLG1 gene is presented. The patients were either homozygous for the 1399G > A (p.A467T) or 2243G > C (p.W748S) mutations or compound heterozygotes for these two mutations. While the clinical features have been reviewed, detailed analysis of their epilepsy is presented for the first time...

The present guideline paper addresses the emergency management of generalized convulsive status epilepticus (CSE) in children and infants older than one month of age. It replaces the previous statement from 1996, and includes a new treatment algorithm and table of recommended medications, reflecting new evidence and the evolution of clinical practice over the past 15 years. The document focuses...

Status epilepticus is defined as continuous seizure activity for greater than 5 minutes or consecutive seizures without regaining consciousness over 5 minutes. Status epilepticus is common in the epilepsy population and is often associated with acute, severe neurological injury or illness such as traumatic brain injury (TBI), intracerebral hemorrhage (ICH), meningitis, or pharmacologic toxicity...

Six patients with status epilepticus (SE) of various etiologies refractory to at least two antiepileptic drugs (AEDs) had complete cessation of their seizures following administration of oral levetiracetam (LEV). Seizure types included convulsive, focal, and nonconvulsive status epilepticus. Effective doses of levetiracetam ranged from 500 to 3000 mg/day, achieving seizure control within 12-96 ...