نتایج جستجو برای: gene transcription

تعداد نتایج: 1249975  

Blinatumomab, the bispecific T cell engager, has been demonstrated as the most successful BsAb to date. Throughout the past decade, vector design has great importance for the expression of monoclonal antibody in Chinese hamster ovary (CHO) cells. It has been indicated that expression plasmids based on the elongation factor-1 alpha (EF-1 alpha) gene and DHFR selection marker can be highly effect...

Drought, an abiotic stress, considered as one of the factors limiting food resources. The plant responses to adaptive to such a condition are accompanied with changes in the expression pattern of some functional as well as regulatory genes. The MYB proteins include a big family of transcription factors which are highly important in regulating development process and immunizing responses of plan...

Journal: :Nature Reviews Drug Discovery 2018

Journal: :Biochimica et biophysica acta 2021

Gene expression, the decoding of DNA information into accessible instructions for protein synthesis, is a complex process in which multiple steps, including transcription, mRNA processing and export, are regulated by different factors. One first steps this involves chemical structural changes chromatin to allow transcription. For such occur, histone tail epigenetic modifications foster binding ...

ژورنال: دانشور پزشکی 2017
اولیا, پرویز, بهزادیان, فریدا, صادری, حوریه, موثر, الهام,

Background and Objective: Adamantanes, amantadine, and rimantadine have been used for many years for prevention and treatment of influenza virus A infections. These drugs are influenza virus M2 protein inhibitors and some amino acids substitutions in transmembrane portion of this protein cause resistance to them. This study was done for survey of adamantane resistance related nucleotide sequenc...

Ghodrat Rahimi-Mianji Gholam-Hossein Askari Hojjat Asadollahpour Nanaei, Saeid Ansari-Mahyari

STATs are a family of latent transcription factors that reside in the cytoplasm of resting cells. The STAT1 transcription factor gene located on the chromosome 2 at interval 60 to 63 cM. This factor upon stimulation with INF gamma, dimerizes and translocate to the nucleus where mediates transcriptional regulation. In this study, we estimated the allele and genotype frequencies of STAT1/Pag<...

ژورنال: دانشور پزشکی 2014
صادقی زاده , مجید, طاهری, طاهر, طریحی, تقی, عباس زاده, حجت اله, عزیززاده دلشاد , علیرضا, نوری زاده , علی , کاظمی, هادی,

Background and Objective: Ciliary neurotrophic factor (CNTF) was originally described as a trophic factor supporting the survival of ciliary ganglion neurons in vitro. CNTF can also promote the survival and differentiation of a variety of nerve cells including sensory, motor, autonomic neurons and oligodendrocytes. To enhance the neurotrophic effect of BMSCs, the CNTF-pSec-tag 2 /hygro A plasmi...

Journal: :hepatitis monthly 0
kai li department of molecular biology on infectious disease, second affiliated hospital, chongqing medical university, chongqing, china shijia ding department of clinical laboratory diagnostics, chongqing medical university, chongqing, china ke chen department of molecular biology on infectious disease, second affiliated hospital, chongqing medical university, chongqing, china dongdong qin department of molecular biology on infectious disease, second affiliated hospital, chongqing medical university, chongqing, china jialin qu department of molecular biology on infectious disease, second affiliated hospital, chongqing medical university, chongqing, china sen wang department of molecular biology on infectious disease, second affiliated hospital, chongqing medical university, chongqing, china

background the hepatitis b virus x (hbx) protein has long been recognized as an important transcriptional transactivator of several genes. human aldo-keto reductase family 1, member c1 (akr1c1), a member of the family of akr1cs, is significantly increased in hbx-expressed cells. objectives this study aimed to investigate the possible mechanism of hbx in regulating akr1c1 expression in hepg2.2.1...

Journal: :avicenna journal of medical biotechnology 0

background: peroxisome proliferator activated receptor gamma (pparγ), a member of nuclear receptor superfamily, comprises two isoforms in mouse. these two isoforms are encoded by different mrnas, which are arisen by alternative promoter usage. there are two promoter regions upstream of pparγ gene. a 3 kb fragment, containing several transcription factor binding sites, acts as pparγ1 promoter re...

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