OBJECTIVES Circulating autoantibodies targeting the H+/K+-ATPase proton pump of gastric parietal cells are considered markers of autoimmune gastritis, whose diagnostic accuracy in atrophic body gastritis, the pathological lesion of autoimmune gastritis, remains unknown. This study aimed to assess autoantibodies against ATP4A and ATP4B subunits of parietal cells H+, K+-ATPase in atrophic body ga...

The detection of gastric premalignant lesions, atrophic gastritis, corpus atrophic gastritis, and intestinal metaplasia, using several potential markers was examined in Costa Rica. Depending on the lesion investigated, from a total of 223 dyspeptic patients, 58 (26.0%), 31 (13.9%), or 23 (10.3%) were histologically diagnosed with atrophic gastritis, corpus atrophic gastritis, or intestinal meta...

BACKGROUND Helicobacter pylori associated gastric cancer arises via a multistage process, with atrophic gastritis being the precursor lesion. Helicobacter pylori is typically acquired in childhood, yet little is known of the prevalence of atrophic gastritis in childhood. AIM To study atrophic gastritis among children from countries with high gastric cancer incidence. METHODS Sections from t...

Gastritis cystica profunda (GCP) is a rare, benign lesion of the stomach characterized by polypoid hyperplasia and/or ulcerated mucosal lesion and cystic dilatation of the gastric glands extending into the submucosa or muscularis propria of the stomach. Its etiology and pathogenesis are still incompletely understood. The most important factor is assumed to be a history of prior gastric surgery....

Cytomegalovirus infection is a common pathogen which rarely cause symptomatic disease in an immunocompetent patient. We present an immocompetent 55 year old male with complaints of pain abdomen and loss of appetite. Upper gastrointestinal endoscopy and radiologic features were suggestive of malignancy and partial gastrectomy was performed. Histopathologic findings were diagnostic of cytomegalov...

Helicobacter pylori infection is associated with many gastroduodenal diseases such as peptic ulcer disease and gastric cancer (Uemura et al., 2001). The organism is the major cause of chronic active gastritis resulting in chronic atrophic gastritis and its end stage, gastric atrophy, which is believed to be a precancerous lesion (Pandey et al., 2010). Intestinal metaplasia, usually associated w...

Gastritis cystica profunda (GCP) is a rare hyperplastic lesion of unclear etiology. Clinical symptoms of GCP are variable and range from nonspeci ic abdominal pain to gastric outlet obstruction. Often the diagnosis of GCP has been dif icult to make as simple esophagogastroduodenoscopy (EGD) guided biopsy can fail to yield the diagnosis. Here, we report a case of GCP that presented in a challeng...

This study examined the inhibitory effects of 4-guanidinobutyric acid (4GBA), an alkaloid, against gastric lesions by assessing the inhibition of Helicobacter pylori (H. pylori) and gastric cancer cells. Acute and chronic gastritis were also observed using HCl/ethanol (EtOH) and indomethacin-induced gastric lesion models, respectively. 4GBA inhibited the growth of H. pylori in a dose dependent ...

BACKGROUND Chronic inflammation plays a causal role in gastric tumor initiation. The identification of predictive biomarkers from gastric inflammation to tumorigenesis will help us to distinguish gastric cancer from atrophic gastritis and establish the diagnosis of early-stage gastric cancer. Phospholipase C epsilon 1 (PLCε1) is reported to play a vital role in inflammation and tumorigenesis. T...