Introduction: Recently, hydrogen sulfide has been introduced as the third gas that acts as a transmitter. It has many physiological and pharmacological roles in the human body. The aim of the present study was to investigate the effect of exogenously administered and endogenously produced H2S on the basal and distention-induced gastric acid secretion in rats. Methods: Forty-nine male Wistar...

Six β-hydroxy-β-aryl propanoic acids were synthesised using a modification of Reformatsky reaction which has already been reported. These acids belong to the aryl propanoic acid class of compounds, structurally similar to the NSAIDs, such as ibuprofen, and an anti-inflammatory activity is thus expected. The aim of this work was to determine anti-inflammatory activity, examine gastric tolerabili...

In the past 30 years, medicine has witnessed an unprecedented evolution in acid-peptic disorder management, fueled by major advances in our understanding of the physiology of acid secretion and the gastric mucosal barrier. The other pivotal development in understanding these disorders has been the recognition of Helicobacter pylori's role in the pathophysiology of peptic ulcer disease,chronic g...

The effect of Methanolic, chloroform and diethel ether extracts of Mimosa pudica was investigated in rats to evaluate the anti-ulcer activity by using three models, i.e. Aspirin, Alcohol and pyloric ligation models experimentally induced gastric ulcer. The parameters taken to assess anti-ulcer activity were volume of gastric secretion, PH, free acidity, total acidity and ulcer index. The result...

The purpose of our study was to systematically evaluate gastric acid output in children with long-lasting gastro-esophageal reflux (GER) in order to assess its mechanism and the need for anti-acid treatment. The investigation was carried out in 20 males and 10 females, aged 7.5 +/- 3.8 years, with prolonged (>15 months) clinical manifestations of GER. All underwent routine ambulatory 24-h esoph...

Objective(s): Transforming growth factor alpha (TGF-α) has been shown to modulate the gastric acid secretion. Therefore, the aim of the present study was to investigate the effect of sodium hydrosulfide (NaHS) on TGF-α expression in gastric mucosa in rats. Materials and Methods: Eighteen rats were randomly divided into 3 groups (6 per group). To determine the effect of NaHS on gene and protein ...

In recent years scientific and technological advancements have been produced many classes of Antiulcer drugs in the medicinal market, such drugs are used to treat the ulcer as quick remedies in people, so we selected some drugs for our studies and market survey then to find out the fast movable antiulcer drug had a potential of some selected antiulcer drugs and the reasons for most leading sale...

ABSTRACT Introduction: Formation of gastric ulcer is a multifactorial process so that vascular changes, mucous secretion, gastric acid and gastrointestinal tract mucous biochemistry are involved in gastric ulcers. Despite therapeutic properties, ibuprofen as a non-steroidal anti-inflammatory drug (NSAID) can cause mucosal lesions in the stomach. In this study, the effect of Matri...

Background: Opioid peptides and their receptors are present in the majority of body tissues including gastrointestinal tract.  Heroin is one of the opioid derivatives that abuse increasingly today.  So far, there is no study on the effect of acute heroin administration on gastric acid and pepsin secretion. Objective:  To define the effect of the acute heroin consumption on basal and vagal-stimu...

This study assessed the effect of profound inhibition of gastric secretion by an H2 antagonist on postprandial gastric emptying of acid and chyme, and on bile acid and pancreatic enzyme secretion under physiological conditions in humans. Six subjects were studied before and while they were given famotidine (40 mg). This study combined a continuous intestinal perfusion technique using 14C-polyet...