conclusion distinct neurochemical and histological structure changes (cortico-striatal-thalamic-cortical cycle) exist in patients with first-episode ocd. 1h-mrs is capable of identifying these changes by assessing metabolic abnormalities. objectives this study aims to use magnetic resonance spectroscopy (mrs) to discover substance-metabolism abnormalities of brain circuits in patients with firs...

Introduction: Psychotropic drugs exert their effects, in part, by increasing neurotrophin levels in the brain. Nerve growth factor (NGF) protein levels after treatment with only a limited number of psychotropics have been determined. The present study was designed in order to evaluate the effects of acute and chronic administration of different psychotropic drugs on NGF protein levels in fiv...

BACKGROUND AND PURPOSE For a better understanding of neuronal network disturbances after stroke, we investigated the changes in the cholinergic system after experimental focal infarct. METHODS We quantitatively evaluated the highly sensitive acetylcholinesterase histochemistry and local glucose utilization 7 days after left middle cerebral artery occlusion in Wistar rats. RESULTS In all rat...

That frontal cortex is involved in visually guided behavior has been known for over a century. Since the pioneering work of Ferrier, several areas in frontal cortex have been identified as having visual responses and playing some role in producing movements of the eyes, head, and limbs. Comprehensive reviews of frontal lobe organization and function have appeared (Fuster, 1989; GoldmanRakic, 19...