نتایج جستجو برای: frailty models
تعداد نتایج: 915874 فیلتر نتایج به سال:
Nonandrogenic Anabolic Hormones Predict Risk of Frailty: European Male Ageing Study Prospective Data
Context Low levels of nonandrogenic anabolic hormones have been linked with frailty, but evidence is conflicting and prospective data are largely lacking. Objective To determine associations between nonandrogenic anabolic hormones and prospective changes in frailty status. Design/Setting A 4.3-year prospective observational study of community-dwelling men participating in the European Male ...
Chronic systematic inflammation and reduced immune system fitness are considered potential contributing factors to the development of age-related frailty, but the underlying mechanisms are poorly defined. This exploratory study aimed to identify frailty-related inflammatory markers and immunological phenotypes in a cohort of community-dwelling adults aged ≥ 55 years. Frailty was assessed using ...
As Canada's population ages, frailty - with its increased risk of functional decline, deterioration in health status, and death - will become increasingly common. The physiology of frailty reflects its multisystem, multi-organ origins. About a quarter of Canadians over age 65 are frail, increasing to over half in those older than 85. Our health care system is organized around single-organ syste...
Although apolipoprotein E (ApoE) polymorphism is associated with variable risks of several illnesses, and with mortality, no persuasive relationship has been demonstrated with frailty. Here, the clinical examination cohort (n=1452 older adults, aged 70+ years at baseline) of the Canadian Study of Health and Aging was evaluated, with 5-year follow-up data. Frailty was defined using both the phen...
OBJECTIVES In India there has been a decline in overall under-five mortality, with some states still showing very high mortality rates. It is argued that there is family clustering in mortality among children aged <5 years. We explored the effects of programmable (proximate) determinants on under-five mortality by accounting for family-level clustering and adjusting for background variables usi...
Shared frailty models are often used to model heterogeneity in survival analysis. There are certain assumptions about the baseline distribution and distribution of frailty. In this paper, we consider compound Poisson distribution as frailty distribution and three different baseline distributions namely, Weibull, generalized exponential and exponential power distribution. With these three baseli...
OBJECTIVES To operationalize and compare three models of frailty, each representing a distinct theoretical view of frailty: as deficiencies in function (Functional Domains model), as an index of health burden (Burden model), and as a biological syndrome (Biologic Syndrome model). DESIGN Cross-sectional analysis. SETTING 2004 wave of the Health and Retirement Study, a nationally representati...
Objectives: Frailty is characterized by an increased vulnerability to stressors. Frail older patients are at increased risk of Emergency Department (ED) visits, hospitalization, and disability. The aim of this study was to determine the relationship between frailty syndrome and polypharmacy in the elderly referred to the emergency department of Ardabil teaching hospitals. Methods & Materials: ...
BACKGROUND In developing countries about 3.5% of children aged 0-5 years are victims of severe acute malnutrition (SAM). Once the morbidity has developed the cure process takes variable period depending on various factors. Knowledge of time-to-cure from SAM will enable health care providers to plan resources and monitor the progress of cases with SAM. The current analysis presents modeling time...
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