A simple, efficient, and cost-effective procedure for the N-tert-butoxycarbonylation and N-formylation of amines (primary, secondary) respectively, with di-tert-butyl dicarbonate and 85% aqueous formic acid under solvent-free condition using B(OSO3H)3/SiO2 (SBSA) as a heterogeneous and recyclable catalyst has been developed. We demonstrated that the resulting catalyst is applicable to various a...

mgo nanopartticels (np-mgo) in average size between 30—130 nm were prepared by sonochemistry method. some phenols have been converted to ortho-hydroxybezaldehyd by ortho-formylation using mgo nanoparticles and (ch2o)n in xylene and subsequently treated with aqueous nh2oh.hcl, affording the corresponding aldoxime in a one-pot procedure. moreover, this one-pot process, with two transformations, o...

MgO nanopartticels (NP-MgO) in average size between 30—130 nm were prepared by sonochemistry method. Some phenols have been converted to ortho-hydroxybezaldehyd by ortho-formylation using MgO nanoparticles and (CH2O)n in xylene and subsequently treated with aqueous NH2OH.HCl, affording the corresponding aldoxime in a one-pot procedure. Moreover, this one-pot process, with two transformations, o...

Application of a dynamic microwave power system in the chemical synthesis of some phenothiazine and quinoline derivatives is described. Heterocyclic ring formation, aromatic nucleophilic substitution and heterocyclic aldehydes/ketones condensation reactions were performed on solid support, or under solvent free reaction conditions. The microwave-assisted Duff formylation of phenothiazine was ac...

A variety of novel ligands have been generated by Vilsmeier formylation of Hantzsch pyridines. These compounds which we call DOTTADs contain two aldehyde, imine or amine functions flanking a central pyridine nitrogen and can be homochiral or crown derivatives. The synthesis and manipulation of these systems is discussed. © 2000 Elsevier Science Ltd. All rights reserved. Some years ago we descri...

Protein synthesis involves two methionine-isoaccepting tRNAs, an initiator and an elongator. In eubacteria, mitochondria, and chloroplasts, the addition of a formyl group gives its full functional identity to initiator Met-tRNA(Met). In Escherichia coli, it has been shown that the specific action of methionyl-tRNA transformylase on Met-tRNA(f)(Met) mainly involves a set of nucleotides in the ac...

Eubacterial translation initiation involves assembly of tRNAfMet, mRNA, initiation factors (IFs) and 30S ribosome in a 30S pre-initiation complex (30S pre-IC), which rearranges and joins 50S ribosome to form 70S IC. Upon releasing IFs, 70S IC becomes elongation-competent 70S. The direct recruitment of initiator tRNA (tRNAfMet) into the ribosomal P-site, crucial in accurate initiation of transla...

The Cover Feature shows a metal-free, N-doped carbon-mediated sustainable catalytic route for selective reductive formylation of quinoline to N-formyl-tetrahydroquinoline and nitroarenes N-formyl anilides via aqueous formic acid mediated transformation. boat (built with chitosan derived from crabs) represents the chitosan-derived carbon catalyst sailing in water containing acid. More informatio...

Here the aromatic formylation mediated by TiCl4 and dichloromethyl methyl ether previously described by our group has been explored for a wide range of aromatic rings, including phenols, methoxy- and methylbenzenes, as an excellent way to produce aromatic aldehydes. Here we determine that the regioselectivity of this process is highly promoted by the coordination between the atoms present in th...