Background: Few studies have been done considering the effectiveness of aqueous extract of cinnamon in neurological diseases. In previous studies, reducing the pain of hydro-alcoholic cinnamon extract in the second phase (chronic) of the formalin test and reduction of inflammation in animal models as well as in humans following cinnamon administration have been emphasized. There are also studie...

the antidepressant effects of aloe vera hydro alcoholic extract at different concentrations were compared with the fluoxetine-treated and the control groups of mice using forced - swimming, fst and open box, oft tests. the mice were evaluated in five groups (control, taking aloe vera at the dosage levels of 150 mg/kg, 300 mg/kg, and 450 mg/kg, and finally fluoxetine at a dose of 10 mg/kg) by th...

Objective: Rosa damascena mill L (R. damascena) is an ornamental plant that has several therapeutic (such as sedative and hypnotic) effects. It also heals depression, grief, nervous stress and tension. In the present study we evaluated antidepressant-like effect of R. damascena using forced swimming test (FST). Material and Methods: Three doses of aqueous extract (15, 60 and 90 mg/kg) was injec...

Objective: Caryophyllus aromaticus mill L (Caryophyllus aromaticus) is a herbal spice plant that has several therapeutic effects. It also heals depression, grief, nervous stress and tension. In the present study we evaluated antidepressant-like effect of Caryophyllus aromaticus using forced swimming test (FST). Material and Methods: Three doses of ethanolic extract (50, 100 and 200 mg/kg) was i...

We have previously found that antitussive drugs inhibit G protein-coupled inwardly rectifying potassium (GIRK) channel currents in brain neurons. Potassium efflux through GIRK channels causes membrane hyperpolarization, and thus plays an important role in the inhibitory regulation of neuronal excitability. Because GIRK channels are coupled to various G protein-coupled receptors including monoam...

Background: Cyclosporine A (CYA) prevents graft rejection after transplantation, interferon-α (IFN-α ) is a natural cytokine prescribed in some types of malignancies and hepatitis C virus. However neurologic complication such as depression side effect chronic use these drugs. Melatonin apart from its on regulating the circadian rhythm, has potent antioxidant inhibits N-methyl-d-aspartic acid (N...

objective: rosa damascena mill l (r. damascena) is a medicinal plant mostly known in the world for its perfume. it also has beneficial effects on stress, tension and depression. in this experiment antidepressant effect of ethanolic extract of r. damascena by forced swimming test (fst) was evaluated. material and methods: animals received ethanolic extract (15, 60 and 90 mg/kg, i.p), imipramine ...

This study investigated the involvement of NMDA receptors and the L-arginine-nitric oxide (NO) pathway in the antidepressant-like effects of zinc in the forced swimming test (FST). The immobility times in the FST and in the tail suspension test (TST) were reduced by zinc chloride (ZnCl(2), 30 and 10-30 mg/kg intraperitoneal (i.p.), respectively). The doses active in the FST and TST reduced loco...

BACKGROUND Several clinical reports have postulated a beneficial effect of the addition of a low dose of risperidone to the ongoing treatment with antidepressants in treatment-resistant depression. METHODS The present study aimed to examine the effect of treatment with fluoxetine or mirtazapine, given separately or jointly with risperidone, on active behavior and plasma corticosterone level i...