Background: Malignant melanoma is the most aggressive form of skin cancer. In contrast to other tumors, the role of estrogen in the initiation and progression of melanoma remains unclear. The aim of this study was to evaluate estrogen receptor beta protein expression in human melanoma tissues and in the benign melanocytic lesions. Method: Twenty-one patients, 11 with cutaneous melanoma and 10 w...

purpose: to report a rare case of ciliochoroidal malignant melanoma presenting as a subconjunctival black-colored mass adjacent to the limbus. patient and findings: a 42-year-old woman presented with a subconjunctival black-colored mass adjacent to the limbus in left eye from 2 years ago. the lesion had increased in size during the previous 2 months. funduscopic examination with scleral depress...

objective we have previously shown that rose bengal (rb) alone, not as a photosensitiser, could induce apoptotic- and non-apoptotic cell death in different melanoma cell lines. to clarify rb-induced toxicity mechanisms, role of caspases and reactive oxygen specious (ros) were studied in melanoma cells. material and methods human melanoma cell lines, me 4405 and sk-mel-28 were cultured in dmem m...

Although gastrointestinal involvement by metastatic malignant melanoma is common but primary gastrointestinal (GI) melanoma has been reported in rare cases. In this study we report two cases of primary gastrointestinal malignant melanoma that one of them is a known case of neurofibromatosis type 1(NF1). Both cases showed no evidence of any lesions in skin and eye. Malignant melanoma of GI tract...

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Primary malignant melanoma of the esophagus (PMME) accounts for 0.1–0.2% of all malignant disease of the esophagus. Ninety-five percent of all melanomas are found in the derma, and only 0.5% are localized in the esophagus (Bisceglia et al. 2011). The prognosis of PMME is unfavorable because most patients are in the advanced stage at diagnosis and rapidly develop lymph node and distant metastase...

Primary malignant melanoma of the esophagus (PMME) is an extremely rare tumor with only scattered cases reported. Although surgical resection has been considered as the best possible option, the prognosis has been nonetheless poor. We report a case of PMME which was treated by surgical resection and additionally followed by chemotherapy. A 60-yr-old man underwent an esophagoscopy due to a 3-mon...

Introduction: Malignant melanoma is a fatal cutaneous neoplasm and one of the fastest growing cancers worldwide. The objective of this study is to evaluate the prevalence of melanoma in different cultural settings and the probable role of clothing for prevention.Materials and Methods: In this cross-sectional study, data about diagnosed melanoma patients in Kerman Province, Iran including age, p...

Introduction: Malignant melanoma is a fatal cutaneous neoplasm and one of the fastest growing cancers worldwide. The objective of this study is to evaluate the prevalence of melanoma in different cultural settings and the probable role of clothing for prevention. Materials and Methods: In this cross-sectional study, data about diagnosed melanoma patients in Kerman Province, Iran including age,...