malignant melanoma of the esophagus is a rare tumor with poor prognosis. the survival of patients is generally less than one year after diagnosis. a case of primary malignant melanoma of the esophagus is presented, who after radical resection of the tumor, is in excellent health, with no evidence of disease 14 months after surgery.

introduction primary malignant esophageal melanoma makes up 0.1% to 0.2% of all esophageal malignancies. most physicians assume malignant melanoma as a skin originated neoplasm, however this type of melanoma can occur anywhere in the gastrointestinal tract especially in the esophagus. thus, it is essential to consider malignant melanoma in differential diagnosis of any esophagus masses. case pr...

vitiligo is a disease that results in depigmented areas in the skin. it may develop at any age but the average age at onset is 20 years. association of vitiligo and melanoma has been commonly reported, but malignancies other than melanoma have been rarely associated with vitiligo. we report a 73‑year‑old patient with new onset vitiligo who developed esophageal adenocarcinoma in the following ye...

Primary esophageal melanoma is an extremely rare malignancy with estimated prevalence of 0.0036 cases per million year. The prognosis the disease unfavorable, in 30-40% patients metastases are detected at time diagnosis, generally accepted approaches to treatment currently insufficiently developed. article presents review literature and describes clinical case a patient primary

The Polycomb group genes are a general class of regulators that are responsible for maintaining homeotic gene expression throughout cell division. Polycomb group expression plays an important role in oncogenesis of several types of human cancer. Melanoma nuclear protein 18 and B-cell-specific Moloney leukemia virus insert site 1 are key Polycomb group proteins. Studies have shown that melanoma ...

S. Valpione1, L.G. Campana2, M. Rastrelli3, A. Sommariva3, A. Vecchiato3, C. Aliberti4, V. Chiarion-Sileni1, C.R. Rossi3 Melanoma and Esophageal Cancer Unit, Veneto Region Research Institute, Padua, ITALY Melanoma and Sarcoma Unit, Veneto Region Oncology Research Institute (IOV-IRCCS), Padua, ITALY Sarcoma and Melanoma Unit, Veneto Region Oncology Research Institute (IOV-IRCCS), Padua, ITALY In...

Primary esophageal malignant melanoma (MM) is rare and extremely aggressive. For pathologists, it can be challenging to diagnose and differentiate from other poorly differentiated malignant neoplasms in the esophagus. Complicating this fact, MM can have divergent differentiation and express nonmelanocytic immunohistochemical markers including epithelial markers (cytokeratins) and rarely neuroen...

The primary malignant melanoma of the esophagus (PMME) is a rare malignant disease, accounting for only 0.1-0.2% of all esophageal neoplasms, and the majority of the patients are diagnosed at advanced stages with poor prognosis. We present here a case of 56-year-old woman with epigastric pain and her endoscopic finding revealed several flat and black pigmented mucosal lesions within the distal ...

Primary malignant melanoma of the esophagus (PMME) is a rare disease with an extremely poor prognosis. We experienced a 79-year-old man with PMME who had unusual endoscopic findings. On endoscopy, an elongated lump was detected on 1 side of the vertical axis of the esophagus. The mass extended progressively for 15 cm along the esophageal longitudinal axis and invaded half of the esophageal circ...

Background and study aims  We report a case of amelanotic malignant melanoma of the esophagus (AMME), an exceedingly rare disease. A 77-year-old Japanese woman presented to our hospital with features suggestive of a middle esophageal submucosal tumor, which was diagnosed pathologically as AMME. The patient underwent thoracoscopic resection of the esophagus and laparoscopic gastric tube reconstr...