NanI Sialidase, CcpA and CodY Work Together to Regulate Epsilon Toxin 1 Production by Clostridium perfringens Type D Strain CN3718 2 3 Jihong Li, John C. Freedman and Bruce A. McClane* 4 Department of Microbiology and Molecular Genetics, University of Pittsburgh School of 5 Medicine, Pittsburgh, PA, USA 15219 6 7 8 Running title: C. perfringens NanI regulates ETX production 9

The aim of this paper is to introduce the notions of ($epsilon, epsilon vee q$)-fuzzy p-ideals, ($epsilon, epsilon vee q$)-fuzzy q-ideals and ($epsilon, epsilon vee q$)-fuzzy a-ideals in BCIalgebras and to investigate some of their properties. Several characterizationtheorems for these generalized fuzzy ideals are proved and the relationshipamong these generalized fuzzy ideals of BCI-algebras i...

Clostridium perfringens type D isolates cause enterotoxemia in sheep, goats, and probably cattle. While the major disease signs and lesions of type D animal disease are usually attributed to epsilon toxin, a class B select agent, these bacteria typically produce several lethal toxins. Understanding of disease pathogenesis and development of improved vaccines are hindered by the lack of a small-...

Many clinical isolates of the human pathogen Neisseria gonorrhoeae contain conjugative plasmids. The host range of these plasmids is limited to Neisseria species, but presence of a tetracycline (tetM) determinant inserted in several of these plasmids is an important cause of the rapid spread of tetracycline resistance. Previously plasmids with different backbones (Dutch and American type backbo...

The Clostridium perfringens epsilon toxin, a select agent, is responsible for a severe, often fatal enterotoxemia characterized by edema in the heart, lungs, kidney, and brain. The toxin is believed to be an oligomeric pore-forming toxin. Currently, there is no effective therapy for countering the cytotoxic activity of the toxin in exposed individuals. Using a robust cell-based high-throughput ...

Clostridium perfringens epsilon toxin (ETX) is the third most lethal bacterial and has been suggested to be an environmental trigger of multiple sclerosis, immune-mediated disease human central nervous system. However, ETX cytotoxicity on primary cells not investigated. In this article, we demonstrate that preferentially binds kills lymphocytes expressing increased levels myelin lymphocyte prot...