Epilepsy is one of the most common neurological diseases, but our understanding of the detailed cellular and molecular mechanisms underlying it remains incomplete. Several pathological changes typically occur in the epileptic brain, including neuronal loss, neurogenesis, neurite growth, and reorganization of extracellular matrix leading to changes in neuronal networks. Many of these features ar...

Extensive data involving several animal models of temporal lobe epilepsy highlight synaptic alterations that likely act synergistically during acquired epileptogenesis. Most of this research has utilized experimental models in which intense electrical activity in adult animals, primarily involving status epilepticus, causes variable neuronal death in the hippocampus and other temporal lobe stru...