Eosinophil chemotaxis and survival within tissues are key components in the development of tissue eosinophilia and subsequent effector responses. In this study, we demonstrate a novel mechanism of eosinophil autoregulation affecting migration and survival mediated through Notch signaling. We show for the first time that human blood eosinophils express Notch receptors and Notch ligands, expressi...

OBJECTIVE We examined prospective connections among parental depressive symptoms, family dysfunction, and eosinophil activity in children with asthma. METHODS 81 children with asthma and their parents completed two laboratory visits across a 1-year period. At baseline and 1 year later, parents reported about their depressive symptoms and family dysfunction. We collected peripheral blood in ch...

Eosinophils and their products play an essential role in the pathogenesis of various reactive and neoplastic disorders. Depending on the underlying disease, molecular defect and involved cytokines, hypereosinophilia may develop and may lead to organ damage. In other patients, persistent eosinophilia is accompanied by typical clinical findings, but the causative role and impact of eosinophilia r...

PURPOSE Mycoplasma pneumoniae pneumonia (MP) is associated with the exacerbation, timing, and onset of asthma. The goal of this study was to elucidate the impact of MP on eosinophil-related hyper-reactive amplification in atopic children. METHODS We studied 48 patients with MP (26 atopic, 22 non-atopic), between 3 and 12 years of age. Serial changes in blood eosinophil counts, serum interleuk...

The large specific granule of the human eosinophil contains a number of low molecular weight, highly basic proteins that have been purified to homogeneity, including the major basic protein (MBP) (1-3), 1 the eosinophil cationic protein (4, 5), and the eosinophil-derived neurotoxin (6, 7). The comparative physicochemical and immunochemical characteristics of these proteins have been examined in...

BACKGROUND Loa loa has emerged as an important public health problem due to the occurrence of immune-mediated severe posttreatment reactions following ivermectin distribution. Also thought to be immune-mediated are the dramatic differences seen in clinical presentation between infected temporary residents (TR) and individuals native to endemic regions (END). METHODS All patients diagnosed wit...