Rosai-Dorfman disease (RDD) is a well-described entity that rarely presents as a solitary intracranial mass. In this case report, we describe progesterone receptor (PR) positivity on immunostain in a recently pregnant patient. The possibility of meningioma was raised. However, the presence of emperipolesis and positive S100 staining in combination with negative EMA stain excluded meningioma fro...

Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy) is a benign systemic proliferative disorder of histiocytes resembling the sinus histiocytes of lymph nodes. The typical clinical features of this disease include bilateral painless lymphadenopathy, fever, and polyclonal hyperglobulinaemia. The condition may present with extranodal involvement in 43% of cases, and cutaneous...

OBJECTIVE To report the clinico-histopathologic features, management and outcome of Rosai-Dorfman disease of the orbit. DESIGN Non-comparative case series. RESULTS Rosai-Dorfman disease of the orbit constituted 0.09% of all ocular specimens received at our Institute, presenting with a firm rubbery mass causing proptosis; bilateral in 4 (57%) cases. The median age at presentation was 13 year...

CRDD: cutaneous Rosai-Dorfman disease LCH: Langerhans cell histiocytosis RDD: Rosai-Dorfman disease R osai-Dorfman disease (RDD) is a benign histiocytic proliferation that most commonly presents with painless bilateral lymphadenopathy and constitutional symptoms such as fever, fatigue, and night sweats. RDD is considered by many to be a reaction pattern with several different manifestations, es...

Rosai-Dorfman disease (also known as sinus histiocytosis with massive lymphadenopathy) is a rare benign proliferative disorder of histiocytes that typically involves the lymph nodes and can also involve extranodal sites. Rosai-Dorfman disease confined to the breast is extremely rare, but important to recognize as it can mimic malignancy. We present the case of a 63-year-old woman who presented ...

AIM To investigate histological and immunohistochemical differences in hepatitis between autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) with AIH features. METHODS Liver needle biopsies of 41 PBC with AIH features and 43 AIH patients were examined. The activity of periportal and lobular inflammation was scored 0 (none or minimal activity) to 4 (severe), and the degree of hepati...

Rosai-Dorfman disease (RDD) is a type of sinus histiocytosis. It rare (1:200000), particularly in children and commonly presents with massive, painless usually bilateral cervical lymphadenopathy along fever weight loss. Leukocytosis, elevated erythrocyte sedimentation rate hypergammaglobulinemia are common. A definitive diagnosis can only be made by histological analysis affected lymph nodes. E...