The quantal responses for somatic movement, and spontaneous and provoked lower oesophageal contractions (motility) were noted at the time of incision in 72 patients aged 40-65 yr, receiving varying concentrations of isoflurane. Probit analysis of the alveolar concentration of isoflurane required to prevent somatic movement revealed an MAC or EC50 (95% confidence limits) of 1.00 (0.82-1.17)% and...

Novel 2-substituted-6-[(4-substituted-1-piperidyl)methyl]-1H-benzimidazoles were designed and synthesized as Ebola virus inhibitors. The proposed structures of the new prepared benzimidazole-piperidine hybrids confirmed based on their spectral data CHN analyses. target compounds screened in vitro for anti-Ebola activity. Among tested molecules, 26a (EC50=0.93 ?M, SI = 10) 25a (EC50=0.64 20) pot...

Todorovic, Slobodan M. and Christopher J. Lingle. Pharmacounderstanding of the diversity within those Ca channels actilogical properties of T-type Ca current in adult rat sensory neuvated at more negative potentials remains more limited. Lowrons: effects of anticonvulsant and anesthetic agents. J. Neurophysvoltage-activated (LVA) Ca current, also called T-type curiol. 79: 240–252, 1998. We have...

The ability of a number of prostaglandin F2 (PGF2 ) analogs to mobilize intracellular Ca [Ca ]i and to compete for [H]PGF2 binding to prostaglandin F2 receptors (FP) was evaluated. Radioligand binding studies measuring displacement of [H]PGF2 by a variety of FP prostaglandin analogs yielded the following rank order of affinities: travoprost acid [( )-16-m-trifluorophenoxy tetranor PGF2 ; ( )-fl...

Introduction and Aim: We examined the effect of pre- and/or post-infection doxycycline on human nasal epithelial cell viability SARS-CoV-2 (clinical strain IHUMI-3) replication in vitro. Materials Methods: Human cells, an vivo target, were derived from healthy donor stem/progenitor cells via vitro differentiation. The exposed to at 0, 0.1, 0.5, 1, 5, 10, 50, 100 ?M before after IHUMI-3 inoculat...

This study was envisaged to explore the impact of pesticide solid waste leachate to Allium cepa (common onion) bulbs. Bulbs exposed to the leachate showed hampered root growth and morphological deformities. At 15% and higher concentrations of leachate after 5 days, gall like swellings were noticed around the mitotic zone (zone of root growth). From the dose response curve, the EC50 values for t...

OBJECTIVES Safranal is a pharmacologically active component of saffron and is responsible for the unique aroma of saffron. The hypotensive effect of safranal has been shown in previous studies. This study evaluates the mechanism for the vasodilatory effects induced by safranal on isolated rat aortas. METHODS To study the vasodilatory effects of safranal (0.2, 0.4 and 0.8 mM), we contracted is...

In the present investigation we have examined the hypothesis that calcium-dependent K+ channels (K(Ca)) are involved in the sodium nitroprusside (SNP)-induced vasodilatation of goat coronary artery. SNP (10(-9)-3 x 10(-6) M), added cumulatively, relaxed K+ (30 mM)-contracted coronary artery ring segments in a concentration-dependent manner with an EC50 of 1.32 x 10(-7) M (95% CL, 0.93-1.86 x 10...

Phlomis bruguieri is a native plant in Iran, which deserves phytochemical study. The aim of this study was evaluation its iridoid contents along with antioxidant capacity. Aerial parts the material were extracted methanol and applied on repeated normal column chromatography using hexane: chloroform (70:30), chloroform: (90:10), (100%). fraction eluted (100%) containing polar glycosides selected...