We read with interest the observation by Khurana et al. (1) regarding the speculative treatment of their case of neonatal diabetes (ND) pending molecular genetic confirmation. The authors report the successful trial of a sulfonylurea in a baby diagnosed with diabetes on day 2 of life in whom an activating KCNJ11mutation was subsequently identified. Khurana et al. suggest a controlled trial of s...

The authors have provided DNA sequencing and RT-PCR data in supporting information files: Figure S1 shows a diagram of the construction of the cagL mutant (A), revertant, and amino acid replacement mutants (B). Figure S2 confirms the cagL mutant, revertant, and amino acid replacement mutants using PCR. Figure S3 shows sequencing results of H. pylori clinical strain Hp1033 wild type, cagL insert...

The PrkC is a serine/threonine kinase, from Hanks super family [1]. The activity of the enzyme increases considerably after phosphorylation of four threonine residues, located on the activation loop (T162, T163, T165, T167) and one serine in the 214 position, located in the C-terminal lobe of PrkC [2]. The purpose of this work was to investigate the structural changes imposed by the phosphoryla...

Abstract D emonetization initiative by Govt. of India in Nov-Dec, 2016 aimed at addressing the issues like black money, hoarding and overall cleansing the monetary system. This paper in this regard attempts to empirically examine the impact of demonetization drive upon the monetary system by taking data of 180 days prior to Nov, 2016. The cointegration results exhibit show a long run ...

Microbial transformation of bile acids at the 3a-, 7aand 12a-hydroxyl positions, under anaerobic conditions, was first reported in Alcaligenes fueculis (Hughes & Schmidt, 1942). Other gut bacteria have also been shown to contain hydroxy steroid dehydrogenases (Aries & Hill, 1970). The most common of the three reactions, 7a-hydroxy steroid dehydrogenation, has been reported in many strains of Es...

None required in se rm -0 07 71 44 0, v er si on 1 8 Ja n 20 13 We thank Dr. Jovani and colleagues for their comments regarding our review on associations between irritable bowel syndrome (IBS) and gut inflammation. Many studies have assessed inflammatory markersin IBS and yielded a considerable amount ofheterogeneous data, which made the link between IBS and inflammation difficult to evaluate....

Purpose: e purpose of this review is to consider the state of oxidative stress, failure of the antioxidant systems and mitochondrial failure as the main physiopathological mechanisms leading to multiple organ dysfunction during sepsis. Principal ndings: Sepsis is a clinical syndrome caused by a severe infection that triggers an exaggerated in ammatory response. Involved in the pathogenesis of s...