BACKGROUND The purpose of this study is to evaluate the efficacy of composite doxorubicinloaded micelles for enhancing doxorubicin radiosensitivity in multicellular spheroids from a non-small cell lung cancer cell line. METHODS A novel composite doxorubicin-loaded micelle consisting of polyethylene glycolpolycaprolactone/Pluronic P105 was developed, and carrier-mediated doxorubicin accumulati...

Background/Aim: The use of doxorubicin is limited due to its toxic effects on normal cells. A substance containing antioxidant properties, such as taraxacum officinale, would be useful in preventing toxicity. This study aimed evaluate the effect officinale doxorubicin-induced damage rat liver. Methods: Forty Wistar albino rats were allocated into four groups. In group 1 (control group), no trea...

The cyclic voltammetry of both bulk manganese sulfate (BMS) and nano manganese sulfate (NMS) were studied using 0.1M KCl supporting electrolyte and glassy carbon working electrode. The redox behavior for both bulk (BMS) and MnSO4 (NMS) sulfate was studied voltammetrically in presence and absence of Doxorubicin (DR) using three electrodes system, silver- silver chloride (Ag/AgCl), pla...

Background: Doxorubicin is a favorite drug for feasting many malignancies. All organs' hepatic toxic effects are destructive and lead to use with caution. Then, it necessary increase antioxidants accompanied doxorubicin reduce its toxicity. Vitamin E an antioxidant harmful consequences. Omega-3 similarly. The healing capacity of E- was investigated together against doxorubicin. Methods: Thirty ...

Magnetic iron oxide nanoparticles have gained a lot of attention in drug delivery systems because they can control a drug pathway to deliver it to the specific site under a magnetic field which is related to their magnetic core and surface coating. Chitosan-coated FeNPs, have prominent antimicrobial and biological properties that make chitosan a promising biopolymer for drug delivery applicatio...

Magnetic iron oxide nanoparticles have gained a lot of attention in drug delivery systems because they can control a drug pathway to deliver it to the specific site under a magnetic field which is related to their magnetic core and surface coating. Chitosan-coated FeNPs, have prominent antimicrobial and biological properties that make chitosan a promising biopolymer for drug delivery applicatio...

To determine the role of the hepatic sinusoidal endothelium in the hepatic disposition of liposomal doxorubicin, we compared the hepatic pharmacokinetics of doxorubicin hydrochloride and the pegylated, liposomal formulation of doxorubicin (Caelyx). The multiple indicator-dilution technique and electron microscopy were used to study the disposition of doxorubicin and liposomal doxorubicin in the...

Doxorubicin as a chemotherapy agent is most widely used in cancer treatment. Long-term use at predetermined dose has side effect, namely cardiotoxicity. Doxorubicin-induced cardiotoxicity considered to be caused by reactive oxygen species (ROS), which also characterized increasing CK-MB enzyme levels the blood. To reduce impact of doxorubin-induced toxicity, study was conducted on natural antio...

Tumor-selective delivery of doxorubicin by a prostate-specific antigen (PSA)-targeted peptide conjugate prodrug of doxorubicin was demonstrated in a nude mouse xenograft model of human prostate cancer. The prodrug (referred to as doxorubicin conjugate) contains doxorubicin linked to a seven-amino acid peptide conjugate that was designed to increase delivery of doxorubicin to tumor sites through...