STUDY OBJECTIVES To determine if the vasodilatory response to the intracoronary injection of ionic and nonionic contrast media in intact pigs is dependent on nitric oxide (NO). The mechanisms responsible for inducing the increase in coronary blood flow in response to the intracoronary injection of contrast media during angiography are still not entirely understood. There is evidence to suggest ...

Intravenous cholangiograms were performed on 100 unselected nonicteric patients using methylglucamine ioglycamide (Biligram). Fifty patients received 10.5 g of contrast medium and 50 received 5.25 g of medium. The contrast medium was injected evenly over five minutes. Side effects were recorded in only 13% of patients and all were mild. Radiographs were taken 10, 30, 60, 90, and 120 minutes aft...

We report in this study the in vivo efficacy of nine 2-substituted quinolines on the Leishmania amazonensis cutaneous infection murine model and on the Leishmania infantum and Leishmania donovani visceral infection murine models. In the case of the L. amazonensis model, quinolines were administered orally at 25 mg/kg twice daily for 15 days. Quinolines 1, 2, 3, and 7 reduced by 80 to 90% the pa...

Assessment of coronary blood flow and the vasodilator reserve capacity of individual coronary arteries in the catheterization laboratory has been hampered by methodologic limitations. We have developed and validated a small Doppler catheter that can subselectively measure phasic coronary blood flow velocity (CBFV). In seven anesthetized calves, CBFV was varied from 0.1 to 5.7 times control CBFV...

Contrast media (CM) are frequently used in diagnostic radiology and in radiotherapy as a diagnostic tool and in treatment planning. Previous studies have demonstrated that these compounds induce chromosomal aberrations. This study evaluates the mutagenic effects induced by the contrast medium Urografina® 292 (meglumine amidotrizoate and sodium-ionic dimmer) in bone marrow cells (BMC) of mice in...

Segmentation of colon lumen from computed tomography (CT) is necessary for 3D virtual colonoscopy. Identifying the residual fluid retained inside the colon after colon-cleansing procedure is one of the major tasks for the segmentation. This work developed a computer algorithm to segment out the residual fluid after the image intensity of the fluid has been enhanced by ingesting an adequate amou...

To evaluate the efficacy of a short course of a lipid formulation of amphotericin B (L-AmB) for the treatment of Mediterranean visceral leishmaniasis (VL), an open prospective study was conducted. Forty-one children with parasitologically confirmed leishmaniasis received L-AmB, 10 mg/kg daily for 2 days. The comparison groups were 30 children who, in a previous study, were treated with L-AmB, 4...

Objective: To study the epidemiological, clinical charactristics and laboratory findings of visceral leishmaniasis (VL) in children. Design: It is a retrospective study, hospital records of all children with diagnosis of VL were reviewed from 1991 through 2003. Setting: Hospitals affiliated to Ahvaz Jondi-Shapour University of Medical Sciences in the southwestern part of Iran. Subjects: Two hun...

Method A 58-year old woman with low grade astrocytoma, who had previously tolerated Gadolinium-based contrasts, was diagnosed with anaphylaxis to Gadobutrol by history of anaphylaxis after intravenous administration and positive skin testing. For these reasons Gadobutrol administration was banned and was given a premedication protocol (steroids and antihistamines) if the patient will require fu...

Treatment of cutaneous leishmaniasis is often difficult. Even though most cutaneous lesions will heal spontaneously, their duration cannot be predicted in an individual case. In general, only large, multiple or diffuse lesions of the face, head and neck need to be considered for therapeutic intervention. Pentavalent antimonials (sodium stibogluconate and meglumine antimoniate) administered intr...