The persistent organic pollutant DDT (1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane) is still indispensable in the fight against malaria, although DDT and related compounds pose toxicological hazards. Technical DDT contains the dichloro congener DDD (1-chloro-4-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene) as by-product, but DDD is also formed by reductive degradation of DDT in the environment...

Previous experimental natural abundance deuterium (NAD) NMR results have shown an odd/even-related alternation in the ((2)H/(1)H) ratio of the methylene groups of fatty acids (ChemBioChem 2001, 2, 425) and, by NAD NMR in CLC, a marked difference between enantiotopic deuterons for each methylenic site (Anal. Chem. 2004, 76, 2827). However, to date, the assignment of the absolute configuration fo...

Endocrine disrupters include a broad spectrum of chemicals such as industrial chemicals, natural estrogens and androgens, synthetic estrogens and androgens. Phytoestrogens are widely present in diet and food supplements; mycoestrogens are frequently found in grains. As human beings and animals are commonly exposed to phytoestrogens and mycoestrogens in diet and environment, it is important to u...

Both singlet oxygen and the hydroxyl radical are generated in mammalian ccHs by UVA (~3Z0---~3{50 rim) and possibly near-visible (~{50--420 nm) radiation. We have modulated the cellular levels of these two reactive oxygen species in order to compare their involvement in the induction of the human heme 0xygenase (I40) gene by broad spectrum UVA/nearvisible light 0LIVA/NVL). Irradiation in deuter...

Both singlet oxygen and the hydroxyl radical are generated in mammalian ccHs by UVA (~3Z0---~3{50 rim) and possibly near-visible (~{50--420 nm) radiation. We have modulated the cellular levels of these two reactive oxygen species in order to compare their involvement in the induction of the human heme 0xygenase (I40) gene by broad spectrum UVA/nearvisible light 0LIVA/NVL). Irradiation in deuter...