نتایج جستجو برای: derived cephalosporinase

تعداد نتایج: 481974  

Journal: :Antimicrobial agents and chemotherapy 2008
Ørjan Samuelsen Mariana Castanheira Timothy R Walsh James Spencer

Purified recombinant VIM-7 possesses efficient penicillinase and carbapenemase activities comparable to those of VIM-2. Cephalosporinase activity was variable and generally lower than those of VIM-1 and VIM-2. A homology model suggests that the VIM-7 Tyr-218 Phe substitution may be responsible for the reduced catalytic efficiency against certain cephalosporins, including ceftazidime and cefepime.

Journal: :Antimicrobial agents and chemotherapy 2011
Pierre Bogaerts Andrea M Hujer Thierry Naas Roberta Rezende de Castro Andrea Endimiani Patrice Nordmann Youri Glupczynski Robert A Bonomo

A new commercial low-density microarray which identifies common extended-spectrum β-lactamase plasmid-mediated cephalosporinase genes, as well as carbapenemase (bla(KPC) and bla(NDM)) genes, was evaluated. We tested 207 clinical and reference/collection isolates of the Enterobacteriaceae possessing different bla genes. Overall, the sensitivity and specificity of the microarray were 100% for the...

Journal: :The Journal of antimicrobial chemotherapy 2007
J D Cavallo D Hocquet P Plesiat R Fabre M Roussel-Delvallez

OBJECTIVES Pseudomonas aeruginosa is a major causative agent of hospital infections. The purpose of this study was to determine the antibiotic susceptibility of P. aeruginosa in a French multicentre study and to investigate the mechanisms of beta-lactam resistance. METHODS Four hundred and fifty non-repetitive strains of P. aeruginosa were collected in 15 French university hospitals in 2004. ...

Journal: :Journal of clinical microbiology 2002
Vivi Miriagou Roxana Filip Gabriela Coman Leonidas S Tzouvelekis

Thirteen Salmonella enterica serotype Typhimurium and one Salmonella enterica serotype Heidelberg strain resistant to expanded-spectrum cephalosporins were isolated from October 2000 to February 2001 from infants with gastroenteritis in Iasi, Romania. In all but one serotype Typhimurium isolate, resistance was due to the production of a CMY-2 cephalosporinase encoded by a nonconjugative plasmid...

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