Purpose: To determine the effect of degenerative disease of the lumbar spine on bone mineral density in the lumbar spine and femoral neck. Materials and Methods: We reviewed radiographs and dual energy x-ray absorptiometry scans of the lumbar spine and hip in 305 Caucasian women with suspected osteoporosis. One hundred and eighty-six patients remained after excluding women less than 40 years of...

Canine degenerative myelopathy (DM) is an adult-onset fatal neurodegenerative disease that occurs in many breeds. The initial upper motor neuron spastic paraparesis and general proprioceptive ataxia in the pelvic limbs progress to a flaccid lower motor neuron tetraparesis. Recently, a missense mutation in the superoxide dismutase 1 (SOD1) gene was found to be a risk factor for DM, suggesting th...

OBJECTIVE To determine the molecules involved in extracellular matrix remodeling and to identify and quantify heparanase isoforms present in herniated and degenerative discs. INTRODUCTION Heparanase is an endo-beta-glucuronidase that specifically acts upon the heparan sulfate chains of proteoglycans. However, heparanase expression in degenerative intervertebral discs has not yet been evaluate...

The spinal cord is one of the most important and most sensitive organs in the body. If it is damaged the nerve cells do not regenerate but are replaced with fibrous tissue. Thus injuries usually result in permanent damage. Therefore, the spinal cord is protected in a very special fashion. It goes through a bony canal within the spine; it is surrounded by protective bone everywhere except over t...

Degenerative spondylolisthesis is a common cause of low back pain and resultant disability in the adult population. The causes degenerative are not entirely understood, though combination anatomic lifestyle factors likely contributes to development this pathology. Here, we report case 38-year-old female presenting with right lower extremity radiculopathy, found have L5-S1 spondylolisthesis, whi...

Adult degenerative lumbar scoliosis is a 3-dimensional deformity defined as a coronal deviation of greater than 10°. It causes significant pain and disability in the elderly. With the aging of the population, the incidence of adult degenerative lumbar scoliosis will continue to increase. During the past decade, advancements in surgical techniques and instrumentation have changed the management ...

MATERIALS AND METHODS. The study of the preliminary results and retrospective chart review of collected clinical and radiographic outcomes in 12 patients who underwent Direct Lateral Interbody Fusion L1-L5 as a treatment for degenerative disc disease, degenerative scoliosis and/or degenerative spondylolisthesis. Clinical outcomes measured include Visual Analog Scale (VAS) and Radiographic outcome.

Degenerative aortic stenosis is currently a public health problem. Affecting the elderly population, this pathology has been showing an increasing prevalence as direct result of population aging. In context, women have greater life expectancy, corresponding to most with degenerative stenosis. Specific characteristics in females are present diagnosis, pathophysiology, anatomical aspects, imaging...

Introduction As a rule dead neurons in the adult central nervous system (CNS) are not replaced nor can their terminals regenerate when their axons are interrupted. Therefore any pathological process causing neuronal death generally has irreversible consequences. Alzheimer disease (AD) is a disabling senile dementia, the loss of reasoning and ability to care for oneself that afflicts about 11% o...