نتایج جستجو برای: cyclin b1

تعداد نتایج: 41655  

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2001
K A Hassan A K El-Naggar J C Soria D Liu W K Hong L Mao

PURPOSE Cyclin B1 plays an important role in control of the G(2)-M transition of the cell cycle. We have shown recently that overexpression of cyclin B1 is associated with poor outcome in patients with early stage squamous cell carcinoma (SCC) of the lung. EXPERIMENTAL DESIGN To determine the role of cyclin B1 in SCC of the tongue, we analyzed tumor specimens from 41 patients with stage II-IV...

Journal: :Cancer research 2004
Uma Kamasani Minzhou Huang James B Duhadaway Edward V Prochownik P Scott Donover George C Prendergast

Farnesyl transferase inhibitors (FTIs) have displayed limited efficacy in clinical trials, possibly because of their relatively limited cytotoxic effects against most human cancer cells. Therefore, efforts to leverage the clinical utility of FTIs may benefit from learning how these agents elicit p53-independent apoptosis in mouse models of cancer. Knockout mouse studies have established that ga...

Journal: :The Journal of Cell Biology 1998
Pei Jin Stephen Hardy David O. Morgan

Mitosis in human cells is initiated by the protein kinase Cdc2-cyclin B1, which is activated at the end of G2 by dephosphorylation of two inhibitory residues, Thr14 and Tyr15. The G2 arrest that occurs after DNA damage is due in part to stabilization of phosphorylation at these sites. We explored the possibility that entry into mitosis is also regulated by the subcellular location of Cdc2-cycli...

2001
Xiao-Ying Yin Linette Grove Nabanita S. Datta Karen Katula Michael W. Long Edward V. Prochownik

We have shown previously that mitotic spindle inhibitors allow the c-Myc oncoprotein to uncouple mitosis from DNA synthesis, resulting in the acquisition of tetraploidy. This can also occur in the absence of spindle inhibition if c-Myc deregulation is combined with inactivation of the p53 tumor suppressor. Under these conditions, cyclin B1 protein is induced but retains its normal cell cycle re...

Journal: :Blood 2003
Lisa A Porter I Howard Cukier Jonathan M Lee

Some cells undergo apoptosis in response to DNA damage, whereas others do not. To understand the biochemical pathways controlling this differential response, we have studied the intracellular localization of cyclin B1 in cell types sensitive or resistant to apoptosis induced by DNA damage. We found that cyclin B1 protein accumulates in the nucleus of cells that are sensitive to gamma radiation-...

Journal: :Cancer research 2001
X Y Yin L Grove N S Datta K Katula M W Long E V Prochownik

We have shown previously that mitotic spindle inhibitors allow the c-Myconcoprotein to uncouple mitosis from DNA synthesis, resulting in the acquisition of tetraploidy. This can also occur in the absence of spindle inhibition if c-Myc deregulation is combined with inactivation of the p53 tumor suppressor. Under these conditions, cyclin B1 protein is induced but retains its normal cell cycle reg...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1997
J Li A N Meyer D J Donoghue

M-phase promoting factor or maturation promoting factor, a key regulator of the G2-->M transition of the cell cycle, is a complex of cdc2 and a B-type cyclin. We have previously shown that Xenopus cyclin B1 has five sites of Ser phosphorylation, four of which map to a recently identified cytoplasmic retention signal (CRS). The CRS appears to be responsible for the cytoplasmic localization of B-...

ژورنال: :مجله تازه های بیوتکنولوژی سلولی - مولکولی 0
اکبر عظیمی akbar azimi ferdowsi university of mashhad, department of plant breeding and biotechnology, iranگروه بیوتکنولوژی گیاهی، دانشکده کشاورزی، دانشگاه فردوسی مشهد، مشهد، ایران فرج ا... شهریاری farajelah shahriary ferdowsi university of mashhad, department of plant breeding and biotechnology, iranگروه بیوتکنولوژی گیاهی، دانشکده کشاورزی، دانشگاه فردوسی مشهد، مشهد، ایران امیر فتوت amir fotovat ferdowsi university of mashhad, department of soil science , iranگروه علوم خاک، دانشکده کشاورزی، دانشگاه فردوسی مشهد، مشهد، ایران خداورد حاجی زاده khodaverd hajizadeh agje sahand university of tabriz, department of chemistry engineering,گروه مهندسی شیمی، دانشگاه صنعتی سهند، تبریز، ایران رضا کاظمی قلعه reza kazemi qale islamic azad university of abhar, department of horticulture science, iranگروه علوم باغبانی، دانشگاه آزاد اسلامی ابهر، ابهر، ایران

سابقه و هدف: اثر سمی کادمیوم بر پارامترهای رشدی و تقسیم سلولی در مناطق مریستمی گیاهان مختلف به اثبات رسیده است. اما با وجود این شواهد، مکانیزم های مولکولی دقیق این فرآیند به خوبی شناخته نشده است. هدف از این تحقیق بررسی اثر کادمیوم بر بیان ژنهای cyclin b1 و cdk-a در نوک ریشه گیاهچه های گندم، برای شناخت مکانیزم های مولکولی تاثیر کاهشی کادمیوم بر رشد است.  مواد و روش ها: نوک ریشه گیاهچه های گندم ر...

2013
Yehong Huang R. Michael Sramkoski James W. Jacobberger

B cyclins regulate G2-M transition. Because human somatic cells continue to cycle after reduction of cyclin B1 (cycB1) or cyclin B2 (cycB2) by RNA interference (RNAi), and because cycB2 knockout mice are viable, the existence of two genes should be an optimization. To explore this idea, we generated HeLa BD™ Tet-Off cell lines with inducible cyclin B1- or B2-EGFP that were RNAi resistant. Cultu...

Journal: :The Journal of Cell Biology 2005
Arne Lindqvist Helena Källström Andreas Lundgren Emad Barsoum Christina Karlsson Rosenthal

Cdc25 phosphatases are essential for the activation of mitotic cyclin-Cdks, but the precise roles of the three mammalian isoforms (A, B, and C) are unclear. Using RNA interference to reduce the expression of each Cdc25 isoform in HeLa and HEK293 cells, we observed that Cdc25A and -B are both needed for mitotic entry, whereas Cdc25C alone cannot induce mitosis. We found that the G2 delay caused ...

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