Both hypergonadotropic hypogonadism and myasthenia gravis can be parts of type II autoimmune polyendocrine syndrome and association between the two disorders has been reported in few cases. A 14 year old male patient with a personal history of bilateral cryptorchidism and ptosis was referred for delayed puberty. Clinical examination revealed eunuchoid habitus, small, soft testes, gynecomastia, ...

Ectopic adrenocorticotropic hormone (ACTH) syndrome is caused most frequently by a bronchial carcinoid tumor or by small cell lung cancer. Medullary thyroid carcinoma (MTC) is a rare etiology of ectopic ACTH syndrome. We describe a case of Cushing syndrome due to ectopic ACTH production from MTC in a 48-year-old male. He was diagnosed with MTC 14 years ago and underwent total thyroidectomy, cer...

224 Indian Dermatology Online Journal | Volume 8 | Issue 3 | May‐June 2017 Sir, A 13‐year‐old boy presented with dark‐colored, itchy skin lesions over both the extremities and back since 6 months. He was previously diagnosed as a case of lichen planus, dermatophytosis, and scabies elsewhere, and was treated unsuccessfully. He was a known case of idiopathic nephrotic syndrome since the age of 7 ...

A40-year-old man with known asthma for 8 years and hypertension for 1.5 years presented with exertional angina. He appeared cushingoid due to self-use of oral steroids which were initially prescribed for his asthma. An echocardiogram showed a mildly dilated left ventricle with segmental dysfunction and preserved global systolic function. A SPECT TC-99 radionuclide scan with treadmill exercise w...

A sequence of amorphous iron r>xide-rich sediments, interbedded with iron-free calcareous nannoplankton oozes, occurs in the basal zones of Sites 74 and 75 of the Deep Sea Drilling Project, immediately overlying basalt. These sediments have affinities with iron and manganeserich sediments previously described from the crest of the East Pacific Rise. It is considered most likely that this sedime...

Glucocorticoids are extremely effective anti-inflammatory therapies, but their clinical use is limited due to severe side effects, including osteoporosis, muscle wasting, fat redistribution, and skin thinning. Here we use heavy water labeling and mass spectrometry to measure fluxes through metabolic pathways impacted by glucocorticoids. We combine these methods with measurements of body composi...

Obesity is a very common medical problem with which modern horses are faced in large part because of the impositions and requirements of modern management practices. In many respects, the tendency for adult horses to develop obesity and the endocrinopathic consequences of obesity-associated insulin insensitivity closely parallels adult-onset diabetes mellitus in human beings. Non-insulin depend...

nonfunctional adrenocortical carcinoma is an extremely rare malignant tumor in children. unlike the functional tumor which is detected early due to its hormonal presentation, nonfunctional tumor is detected at a later stage. here we report a case of a 10 year old girl who presented with abdominal mass and symptoms of short duration. no hypertension and cushingoid features were seen. serum alpha...

Eight patients with infection due to human immunodeficiency virus type 1 developed fat pads at the bases of their necks a median of 22 weeks (range, 4-61 weeks) after initiation of protease inhibitor therapy. This finding was seen in association with the use of each of the available protease inhibitors. The patients had no other cushingoid features or histories of corticosteroid use, and all ha...