Magnetic resonance imaging (MRI)–negative Cushing disease is one of the most difficult and challenging surgical cases in both pituitary skull base surgery. Experience gained by a sequence success and, unfortunately, failure, which results hard-fought experience with these cases. There are variety established novel techniques that would benefit from high-quality video documentation, could help s...

Members of the ErbB family of cell surface tyrosine kinase receptors are important targets for cancer treatment because they frequently contribute to the pathogenesis of malignancy. In this issue of the JCI, Fukuoka et al. generate data that suggest that using a tyrosine kinase inhibitor (TKI) against epidermal growth factor receptor (EGFR; also known as ErbB1) may be a novel approach for treat...

Arq Bras Endocrinol Metab 2007;51/8 Celebration of the 75th Anniversary of Cushing’s Syndrome IT IS OPPORTUNE THAT THIS ESPECIAL issue of the Brazilian Journal of Endocrinology and Metabolism comes out just in time to celebrate the 75th anniversary of the original description of the disease that turned out to be known as Cushing’s syndrome. Harvey Williams Cushing (April 8, 1869 — October 7, 19...

Adrenocorticotropin-independent adrenal hyperplasias are rare diseases, which are classified into macronodular (>1 cm) and micronodular (≤1 cm) hyperplasia. Micronodular adrenal hyperplasia is subdivided into primary pigmented adrenocortical disease and a limited or nonpigmented form 'micronodular adrenocortical disease (MAD)', although considerable morphological and genetic overlap is observed...

Context Carney complex (CNC) is a syndrome characterized by hyperplasia of endocrine organs and may present with clinical features of Cushing syndrome and acromegaly due to functional adrenal and pituitary gland tumors. CNC has been linked to mutations in the regulatory subunit of protein kinase A type I-alpha (PRKAR1A) gene. Design Tissue samples were taken from the hypothalamus or thalamus ...

 Abstract Thymic carcinoid is an uncommon neoplasm that can present with Cushing syndrome. We report a 39-year old woman with symptoms of Cushing syndrome secondary to thymic carcinoid and synchronous with tuberculous lymphadenitis and pulmonary tuberculosis. 

The objective of this study is to report three cases of paraneoplastic or ectopic Cushing syndrome, which is a rare phenomenon of the adrenocorticotropic hormone (ACTH)-dependent Cushing syndrome. Three cases are reported in respect of clinical presentation, diagnosis and treatment in addition to relevant literature review. The results showed that ectopic ACTH secretion can be associated with d...

could delineate Cushing's character and characteristics quite as well as has Cushing himself. The reader may well wish that more of such material had been included. The book is singularly free of observable technical errors, the most significant one is the statement on page 88 where we find that Cushing sailed from Boston on the 30th of June to arrive (says Cushing) "in Liverpool harbor on June...

abstract thymic carcinoid is an uncommon neoplasm that can present with cushing syndrome. we report a 39-year old woman with symptoms of cushing syndrome secondary to thymic carcinoid and synchronous with tuberculous lymphadenitis and pulmonary tuberculosis.