نتایج جستجو برای: connexin43

تعداد نتایج: 1453  

Journal: :The Biochemical journal 2009
Joell L Solan Paul D Lampe

Vertebrate gap junctions, composed of proteins from the connexin gene family, play critical roles in embryonic development, co-ordinated contraction of excitable cells, tissue homoeostasis, normal cell growth and differentiation. Phosphorylation of connexin43, the most abundant and ubiquitously expressed connexin, has been implicated in the regulation of gap junctional communication at several ...

Journal: :Cancer research 1992
L X Zhang R V Cooney J S Bertram

Epidemiological evidence and studies in whole animals and cell culture have indicated that carotenoids have cancer chemopreventive action. In mouse C3H10T1/2 cells, this activity is highly correlated with the ability of carotenoids to up-regulate gap junctional intercellular communication. Here, we report that in mouse cells, carotenoids increase the expression of connexin43, a gene that encode...

Journal: :Circulation research 1993
R G Gourdie C R Green N J Severs R H Anderson R P Thompson

The gap-junctional proteins connexin43 and connexin42 have been shown to be expressed in the developing and mature avian heart, but their respective spatiotemporal distributions are unknown. In the present study, we have immunolocalized connexin42 in the conduction tissues of the adult avian heart (nonbranching bundle, bundle branches, and Purkinje fibers) and vascular endothelial cells. Connex...

2005
A. P. Moreno J. C. Saez G. I. Fishman D. C. Spray

Connexin43 is the major gap protein in the heart and cardiovascular system. Single channel recordings of human connexin43 gap junction channels exogenously expressed in transfected SKHepl cells demonstrate two discrete classes of channel events, with unitary conductances of predominantly 60 to 70 and 90 to 100 pS when recorded with an internal solution containing CsCl as the major current-carry...

Journal: :Journal of cell science 2004
Céline Fiorini Baharia Mograbi Laurent Cronier Isabelle Bourget Xavier Decrouy Marielle Nebout Bernard Ferrua André Malassine Michel Samson Patrick Fénichel Dominique Segretain Georges Pointis

Gap junctional intercellular communication is involved in the control of cell proliferation and differentiation. Connexin33, a member of the multi-gene family of gap junction proteins, exerts an inhibitory effect on intercellular communication when injected into Xenopus oocytes. However, the molecular mechanisms involved remain to be elucidated. Our results show that connexin33 was only express...

Journal: :Carcinogenesis 2001
E Rivedal H Opsahl

Gap junction intercellular communication (GJIC) is involved in the regulation of many cellular processes. The gap junction channels are made up of connexins and the flow of polar low molecular weight molecules through these channels is inhibited by several groups of substances, such as tumour promoters and growth factors. The phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA), chlordane a...

Journal: :Circulation. Cardiovascular genetics 2015
Indra Lübkemeier Felicitas Bosen Jung-Sun Kim Philipp Sasse Daniela Malan Bernd K Fleischmann Klaus Willecke

BACKGROUND Sudden infant death syndrome (SIDS) describes the sudden, unexplained death of a baby during its first year of age and is the third leading cause of infant mortality. It is assumed that ≤20% of all SIDS cases are because of cardiac arrhythmias resulting from mutations in ion channel proteins. Besides ion channels also cardiac gap junction channels are important for proper conduction ...

Journal: :Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2000
E C Beyer J Gemel K H Seul D M Larson K Banach P R Brink

Intercellular communication may be regulated by the differential expression of subunit gap junction proteins (connexins) which form channels with differing gating and permeability properties. Endothelial cells express three different connexins (connexin37, connexin40, and connexin43) in vivo. To study the differential regulation of expression and synthesis of connexin37 and connexin43, we used ...

Journal: :Circulation research 1991
M J van Kempen C Fromaget D Gros A F Moorman W H Lamers

The developmental appearance and spatial distribution pattern of gap junctions were studied in prenatal and adult rat hearts. Gap junctions were visualized immunohistochemically with an antibody raised against a unique cytoplasmic epitope of connexin43, and the spatial distribution pattern was determined by three-dimensional reconstruction. The results demonstrate that from embryonic day 13 onw...

2016
Kristin M French Joshua T Maxwell Srishti Bhutani Shohini Ghosh-Choudhary Marcos J Fierro Todd D Johnson Karen L Christman W Robert Taylor Michael E Davis

Cardiac progenitor cells (CPCs) have rapidly advanced to clinical trials, yet little is known regarding their interaction with the microenvironment. Signaling cues present in the microenvironment change with development and disease. This work aims to assess the influence of two distinct signaling moieties on CPCs: cyclic biaxial strain and extracellular matrix. We evaluate four endpoints for im...

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