Malaria is among the factors thought to be involved in the pathogenesis of endomyocardial fibrosis (EMF), a restrictive cardiomyopathy of unclear etiology, with no specific therapy, which affects predominantly children and adolescents. In Africa, regions endemic with EMF are also areas with high prevalence of malaria. We studied 47 consecutive children aged 5- to 15-years old and concluded that...

Severe (complicated) malaria caused by Plasmodium falciparum kills over a million people every year. The annual death toll can be as high as one in 100 children under the age of five(1). Intravenous infusion of quinine is recommended as an initial therapy for these children. Recent years have witnessed increasing use of artemisinin derivatives (mainly artesunate) in the treatment of severe mala...

Malaria is an infectious protozoan parasitic disease transmitted by Anopheles spp mosquito. As a entity, malaria still major global health problem due to its morbidity and mortality that endangered millions of individuals inhabitants in tropical region. Kidney derangement moderately frequent severe caused the species P. falciparum also malariae, but seldom this condition has been reported vivax...

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Background: Renal failure is a complication of severe malaria, and rhabdomyolysis with myoglobinuria is an uncommon cause. We report an unusual case of severe falciparum malaria with dengue coinfection complicated by acute renal failure and myoglobinemia, myoglobinuria but a normal creatine kinase (CK).

Association of symmetric peripheral gangrene (SPG) with falciparum malaria infection is a relatively uncommon clinical entity. Here we report a case of complicated falciparum malaria with SPG involving both lower limbs from the mid-calf downwards, probably due to antibody mediated vasculitis.

We report two cases of Plasmodium vivax malaria (both aged 12 years) complicated by seizures and symptoms of diffuse meningoencephalitis. One had predominantly meningeal signs while in the other, purely encephalitis features were present. Both cases were treated with artesunate. Rarely, cerebral malaria is a presenting complication or occurs during the course of P. vivax infection.

Abstract This case report describes the clinical presentation, diagnosis, and management of a 34-year-old male patient with malaria caused by Plasmodium falciparum, complicated immune hemolytic anemia. The initially presented one-day history fever feeling unwell, but diagnosis was missed. Four days later, during second follow-up visit, administered Artemisinin Piperaquine tablets. Despite this ...

BACKGROUND Artemisinin derivatives may have advantages over quinoline drugs for treating severe malaria since they are fast acting and effective against quinine resistant malaria parasites. OBJECTIVES The objective of this review was to assess the effects of artemisinin drugs for severe and complicated falciparum malaria in adults and children. SEARCH STRATEGY We searched the Cochrane Infec...