PURPOSE This study was designed to improve the in vivo pharmacokinetics of long-circulating vincristine sulfate (VS)-loaded liposomes; three different long-circulating materials, chitosan, poly(ethylene glycol)-1,2-distearoyl sn-glycero-3-phosphatidylethanolamine (PEG-DSPE), and poly(ethylene glycol)-poly-lactide-co-glycolide (PEG-PLGA), were evaluated at the same coating molar ratio with the c...

The antimicrobial effect of the polyamide 6/66-chitosan blend obtained by extrusion and chitosan-coated plastic films was compared with pure chitosan films and chitosan solution against Escherichia coli, Listeria monocytogenes and Bacillus cereus. The films from polyamide 6/66-chitosan blend had no antibacterial activity, and the chitosan plastic film coating (bilayer system) showed only contac...

Capsaicin has known health beneficial and therapeutic properties. It is also able to enhance the permeability of drugs across epithelial tissues. Unfortunately, due to its pungency the oral administration of capsaicin is limited. To this end, we assessed the effect of nanoencapsulation of capsaicin, under the hypothesis that this would reduce its pungency. Core-shell nanocapsules with an oily c...

Mesoporous silicon is a biocompatible, biodegradable material that is receiving increased attention for pharmaceutical applications due to its extensive specific surface. This feature enables to load a variety of drugs in mesoporous silicon devices by simple adsorption-based procedures. In this work, we have addressed the fabrication and characterization of two new mesoporous silicon devices pr...

This article reports the investigation of mechanical properties of alginate-chitosan microcapsules and the relation to protein delivery. For microscale compression testing, a system based on a microelectromechanical systems (MEMS) capacitive force sensor was developed. The bulk microfabricated capacitive force sensors are capable of resolving forces up to 110 microN with a resolution of 33.2 nN...

Extracorporeal filter cartridges, filled with an activated carbon bead (ACB) adsorbent, have been used for removal of overdosed cancer drugs from the blood. Coatings on adsorbent matrices, poly(methyl methacrylate) (PMMA)/activated carbon bead and PMMA/chitosan/heparin/ACB composites, were tested to improve their biocompatibility and blood compatibility. PMMA coating on ACBs was accomplished in...

In this work, a coating of chitosan onto alginate hydrogels was realized using the water-soluble hydrochloride form of chitosan (CH-Cl), with the dual purpose of imparting antibacterial activity and delaying the release of hydrophilic molecules from the alginate matrix. Alginate hydrogels with different calcium contents were prepared by the internal setting method and coated by immersion in a C...

Iron oxide nanoparticles were synthesized and coated with silica by conventional coprecipitation method. Silica coated iron oxide nanoparticles were surface functionalized with chitosan. Silica coating and chitosan functionalization were confirmed by FTIR and TG-DTA analysis. XRD pattern revealed that the pure phase of Fe3O4 was retained even after coating. Particles of average size 12 nm were ...

The effect of chitosan coating combined with green tea extract (GTE) on the quality of tigertooth croaker (Otolithes ruber) fillets including chemical, microbiological, texture, color and sensory properties during 16 days of refrigerated storage was investigated. The changes of color different were significantly retared, and the texture parameteres and sensory scores were significantly improved...