Bistability in periodically paced cardiac tissue is relevant to cardiac arrhythmias and its control. In the present paper, one-dimensional tissue of the phase I Luo-Rudy model is numerically investigated. The effects of various parameters of pacing signals on bistability width are studied. The following conclusions are obtained: (i) Pacing can be classified into two types: pulsatile and sinusoi...

Multistability is a crucial recurring theme in cell signaling. Multistability is attributed to the presence of positive feedback loops, but the general condition and essential mechanism for realizing multistability remain unclear. Here, we build a generic circuit model comprising two transcription factors and a microRNA, representing a kind of core architecture in gene regulatory networks. The ...

Many neurons display bistability--coexistence of two firing modes such as bursting and tonic spiking or tonic spiking and silence. Bistability has been proposed to endow neurons with richer forms of information processing in general and to be involved in short-term memory in particular by allowing a brief signal to elicit long-lasting changes in firing. In this paper, we focus on bistability th...

The living cell is an open nonequilibrium biochemical system, where ATP hydrolysis serves as the energy source for a wide range of intracellular processes including the assurance for decision-making. In the fission yeast cell cycle, the transition from G2 phase to M phase is triggered by the activation of Cdc13/Cdc2 and Cdc25, and the deactivation of Wee1. Each of these three events involves a ...

We solve a conjecture on multiple nondegenerate steady states, and prove bistability for sequestration networks. More specifically, we that any odd number of species, production factor, the fully open extension network admits three positive two which are locally asymptotically stable. In addition, provide non-empty set in parameter space where bistability, present p...

The authors have developed a mathematical model of regulation of expression of the Escherichia coli lac operon, and have investigated bistability in its steady-state induction behaviour in the absence of external glucose. Numerical analysis of equations describing regulation by artificial inducers revealed two natural bistability parameters that can be used to control the range of inducer conce...

we solve the coupled mode equations governing the chalcogenide nonlinear fiber bragg gratings (fbgs) numerically, and obtain the bistability characteristics. the characteristics of the chalcogenide nonlinear fbgs such as: switching threshold intensity, bistability interval, on-off switching ratio are studied. the effects of fbg length and its third order nonlinear refractive index on fbg charac...

The nature of bistability in large gas-phase chemical networks of dense interstellar clouds at 10 K is examined. The dependence of bistability on the parameter ζ/nH, the cosmic ray ionization rate divided by the total hydrogen density, for a wide range of elemental depletions is investigated in detail. We confirm that bistability can exist at steady-state for a range of ζ/nH, but we also confir...

We explore the potential of direct spectroscopy of ultranarrow optical transitions of atoms localized in an optical cavity. In contrast to stabilization against a reference cavity, which is the approach currently used for the most highly stabilized lasers, stabilization against an atomic transition does not suffer from Brownian thermal noise. Spectroscopy of ultranarrow optical transitions in a...

The purpose of the presented work is to introduce the novel design of electrostatic energy harvester using bistable mechanism with compensational springs in gravity field capable of providing the output of several μW under the excitation of extremely small amplitude (up to 0.2g) and low frequency (10-100Hz). Presented energy harvester uses the bistable hysteresis modification to achieve low-fre...