In this study we evaluated long-term functional results of different methods of retinoblastoma treatment including chemoreduction with carboplatine, etoposide and vincristine, chemothermotherapy, cryotherapy, diode laser thermotherapy, photocoagulation and external beam radiation. The group investigated involved 54 eyes of 43 patients treated in the period from 1985 to 1998. Thirty-two patients...

OBJECTIVE To determine the clinical manifestations and results of current treatment for patients with retinoblastoma (Rb) in a tertiary care eye hospital in the north west of Pakistan. STUDY DESIGN Case series. PLACE AND DURATION OF STUDY Al-Shifa Trust Eye Hospital, Rawalpindi, Pakistan, from January 2006 and December 2009. METHODOLOGY The data of 139 patients diagnosed as having retinob...

BACKGROUND Retinoblastoma is the most common primary intraocular malignancy in children. The management of retinoblastoma is complex and depends on several factors. METHODS This review provides an update on current and emerging therapeutic options for retinoblastoma. The medical literature was searched for articles relevant to the management of retinoblastoma. The results of prospective and r...

PURPOSE To report a case of a 29-month-old male with familial, bilateral retinoblastoma with orbital recurrence following aggressive laser treatment. METHODS This is a retrospective case report of a single patient. RESULTS A 3-week-old male was diagnosed with familial, bilateral retinoblastoma (group D OD, group A OS), and treated with 6 cycles of systemic chemotherapy and laser treatment. ...

Purpose: To evaluate the effectiveness of chemoreduction (CRD) for globe saving in patients with intraocular retinoblastoma Methods: In this interventional case series all patients with intraocular retinoblastoma were included and classified according to the international classification of retinoblastoma (ICRB) from group A to E. Six cycles of intravenous Vincristine, Etoposide and Carboplatin ...

AIM The purpose of this study was to evaluate the outcomes of infants diagnosed with retinoblastoma before 6 months of age, including the need for chemoreduction (CRD). In this age group, dosage of CRD was reduced due to its potential for toxicity. METHODS This is a retrospective review from 2000 to 2009 that includes 126 eyes of 72 infants (18 unilateral, 54 bilateral). Systemic CRD was admi...

pletely in the left eye. The NVI disappeared, leaving no trace on clinical or fluorescein angiography, and intraocular pressures remained lower than 22 mm Hg. At 5 months’ followup, both eyes remained stable without NVI or glaucoma. Case 2. A 7-month-old girl was initially seen with bilateral leukocoria from bilateral advanced retinoblastoma. Both eyes showed retinal detachment, subretinal seed...

Retinoblastoma (RB) is the most common childhood malignant intraocular tumor. Although enucleation and external beam radiotherapy have been historically used, today the most commonly used eye-sparing approach is chemotherapy. Chemotherapy can be used in both intraocular and extraocular RB cases. Chemotherapeutic agents may be applied in different ways, including systemic, subconjunctival, intra...

BACKGROUND We describe a case of a recurrent ocular surface squamous neoplasia (OSSN) in a 37-year-old male with a mass at the infero-temporal quadrant along with an isolated primary lesion at the upper nasal quadrant for the last five months with a past history of surgical excision 7 years ago for a nodular mass in the same eye. The mass showed delayed response to Mitomycin C (MMC) therapy and...