Abstract The leaf vasculature plays a key role in solute translocation. Veins consist of at least seven distinct cell types, with specific roles transport, metabolism, and signaling. Little is known about vascular cells, particular the phloem parenchyma (PP). PP effluxes sucrose into apoplasm as basis for loading, yet has been characterized only microscopically. Here, we enriched cells from Ara...

Abstract Tumor cells have different metabolism from normal cell, which is called as cancer metabolism. In cells, asparagine provided by synthetase (ASNS) aspartate. On the other hand, in tumor needed to be taken outside addition synthesized ASNS within because of rapid growth cells. Glioblastoma one aggressive brain tumors, and temozolomide frequently used. After glioblastoma acquire resistance...

Melanoma cells exhibit numerous transcriptional cell states including developmental programs such as neural crest-like and pigmented melanocytic cells. These endow tumorigenic properties like sustained growth, immune evasion, therapy resistance, metastasis. Here, we use a zebrafish melanoma model to identify program linking the state dependence on lipid droplets, specialized organelle responsib...

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A multifunctional, ubiquitous molecule, adenosine acts at cell-surface G protein-coupled receptors, as well numerous enzymes, including protein kinases and adenylyl cyclase. Extracellular is thought to be produced either by export or metabolism, predominantly through ecto-5’-nucleotidase activity (also producing inorganic phosphate). It inactivated extracellular metabolism via deaminase ammonia...