We examined the role of interleukin (IL)-18 and cytokine-induced neutrophil chemokines (CINC)-1 and CINC-3 in the neutrophil release of superoxide anion (O2-) and elastase following alcohol/ethanol (EtOH) and burn injury. Male rats (approximately 250 g) were gavaged with EtOH to achieve a blood EtOH level of approximately 100 mg/dl before approximately 12.5% total body surface area burn or sham...

HYPOTHESIS High-dose ascorbic acid (vitamin C) therapy (66 mg/kg per hour) attenuates postburn lipid peroxidation, resuscitation fluid volume requirements, and edema generation in severely burned patients. STUDY DESIGN AND SETTING A prospective, randomized study at a university trauma and critical care center in Japan. SUBJECTS AND METHODS Thirty-seven patients with burns over more than 30%...

Histamine is an important mediator contributing to oedema formation after thermal injury. Tissue histamine concentrations have been previously determined by analyzing tissue biopsies. The microdialysis method enables continuous collection of samples from the extracellular tissue fluid. In this experimental burn study on pigs samples from the extracellular fluid for histamine analysis were colle...

BACKGROUND Arnebia euchroma ointment (AEO) has been used in Iranian traditional medicine for burn wound healing. OBJECTIVES The aim of this study is to evaluate wound healing efficacy of AEO in burn wounds after fractional Co2 laser. PATIENTS AND METHODS This split-face, single-blinded, single-center clinical study was performed in Shohada-e-Tajrish Hospital, Tehran, Iran. A total of 26 sub...

Abstract Background Inhalation lung injury occurs in almost one-third of all serious burns and is responsible for a considerable proportion burn patient fatalities each year. History closed space fire or unconsciousness at the accident site, occurrence pharyngeal facial burns, hoarseness, wheezing, laboratory tests that include blood gas abnormalities Carboxyhemoglobin levels ˃ 10% are used to ...

Children, especially younger ones, form a risky group among burned patients. A severe burn injury is not only a life threatening problem for injured children, but may have serious physical, psychosocial and financial effects on them, their families and the society. Although the number of burned victims among children has been decreasing in most of the European countries, including Croatia, duri...

Ammonia is now frequently used in armed robberies by assailants, who possibly misguidedly imagine that it is an easy and safe method of temporarily incapacitating their victim. Nevertheless, two case histories are presented to illustrate the early rise of intraocular pressure which may occur after excessive exposure of the eye to ammonia. The clinical appearance in many respects mimicked that o...

Hyperoncotic albumin proved ineffective as a plasma volume expander in the resuscitation of four acutely burned children. Hypovolemia and pulmonary edema were apparently intensified by an obligatory fluid shift following tissue extravasation of protein. We conclude that, when used, hyperoncotic albumin should be suspended in a sufficient volume of saline to produce a solution isotonic and iso-o...

Several reports have documented that modern burn patients receive far more resuscitation fluid than predicted by the Parkland formula-a phenomenon termed "fluid creep." This article reviews the incidence, consequences, and possible etiologies of fluid creep in modern practice and uses this information to propose some therapeutic strategies to reduce or eliminate excessive fluid resuscitation in...