OBJECTIVE This study aimed to assess the associations between parity, mode of delivery, and pelvic floor disorders. METHODS The prevalence of pelvic organ prolapse, stress urinary incontinence, overactive bladder, and anal incontinence was assessed in a random sample of women aged 25-84 years by using the validated Epidemiology of Prolapse and Incontinence Questionnaire. Women were categorize...

BACKGROUND The purpose of the present study was to determine how acute adult and/or prior early-in life (EIL; P14-P16) exposure to bladder inflammation affects bladder content of calcitonin gene related peptide (CGRP) and substance P (SP). Estrous cycle influences were also studied in the adult-treatment conditions. METHODS In Experiment 1, intravesical zymosan or isoflurane anesthesia alone ...

The case report of Marti et al. highlights the interest of behavioral and cognitive therapy (BCT) in the treatment of urinary disorders, specially in overactive bladder (OAB). Despite BCT efficacy, and other similar techniques [1], this therapeutic option is not often used probably for 3 reasons: poor patient acceptance for a such treatment, cost of the BCT, and finally, lack of knowledge of th...

botulinum toxin (bt) is a potent presynaptic neuromuscular blocking agent which induces selective, reversible muscle weakness for months when injected intramuscularly.during recent years bt has revolutionized the treatment of previously intractable symptoms of detrusor overactivity. based on a systematic search of the pubmed database,a review of the current literature on the use of onabotulinum...

Interstitial cystitis and bladder pain syndrome (IC/BPS) are terms used to describe a heterogeneous chronic pelvic and bladder pain disorder. Despite its significant prevalence, the disease etiology is not well understood and providing diagnosis and treatment can be challenging. In our study, published recently in the Journal of Urology (Colaco et al., 2014), we describe the use of microarrays ...

Multiple sclerosis is a common neurologic disorder that often affects the genitourinary system. One of the most common symptoms of multiple sclerosis is the hyperactive bladder. These patients will have symptoms that may affect their lifestyle, such as urinary incontinence, urgency, and frequency. They may also suffer from debilitating urinary tract symptoms, such as frequent or recurrent urina...

INTRODUCTION Emphysematous cystitis is a very rare complicated urinary tract infection characterized by air in the bladder wall. CASE PRESENTATION We report two clinical cases of emphysematous cystitis of an 83-year-old Caucasian woman with diabetes mellitus and a 78-year-old Caucasian man with no past medical history. They presented with severe confusion and abdominal distension. Emphysemato...

PURPOSE OF REVIEW Nocturnal enuresis is an especially common problem with the potential to have an appreciable negative impact on the emotional health of a child. RECENT FINDINGS Our understanding of the pathogenesis continues to improve. A disorder of sleep arousal, a low nocturnal bladder capacity, and nocturnal polyuria are the three factors that interrelate to cause nocturnal enuresis. Co...

Amyloidosis is a disorder of protein folding characterized by extracellular aggregation and deposition of amyloid protein fibrils. Light-chain amyloidosis, also known as primary systemic amyloidosis, is the most common form of the disease. We present a case of an 84-year-old male with a history of systemic primary amyloidosis causing genitourinary, cardiac, and autonomic dysfunction who present...