نتایج جستجو برای: beta cells
تعداد نتایج: 1519906 فیلتر نتایج به سال:
transforming growth factor-beta (tgf-β) is one of the most important cytokines implicated in growth, differentiation, repair and also the pathogenesis of the lung fibrosis by its stimulatory effect on extracellular matrix deposition. pulmonary epithelial cells are considered as a source of tgf-β in lung. substance p (sp), as a neuroimmunomodulator has elevated levels in inflamed airways and alt...
NHL is the most common hematologic cancer in adults. Rituximab is the FDA approved treatment of relapsed or refractory low grade B-cell Non-Hodgkin Lymphoma (NHL). But patients eventually become resistant to rituximab. Since lymphocytes and lymphoma cells are highly radiosensitive, low grade NHL that has relapsed or refractory to standard therapy is treated by RIT in which a beta-emitting radio...
Introduction: In adult mammalian brain, neural stem cells are isolated from both the dentate gyrus and subventricular zone. This study aimed to isolate neural stem cells from adult rat subventricular zone and differentiate them into neurons and astrocytes. Methods: In this study, the whole brain was removed after full anesthesia and creating cervical dislocation. Under a microscope, subv...
Background & Objective: Type1 diabetes is characterized by autoimmune destruction of pancreatic β cells, leading to reduced insulin secretion. Differentiation of mesenchymal stem cells (MSCs) into β-like cells offers new ways of diabetes treatment. MSCs can be insulated from the human umbilical cord tissue and differentiate into insulin-producing cells. Material & Methods: Human um...
NHL is the most common hematologic cancer in adults. Rituximab is the FDA approved treatment of relapsed or refractory low grade B-cell Non-Hodgkin Lymphoma (NHL). But patients eventually become resistant to rituximab. Since lymphocytes and lymphoma cells are highly radiosensitive, low grade NHL that has relapsed or refractory to standard therapy is treated by RIT in which a beta-emitting radio...
Introduction: Interferon (IFN) was first introduced by Isaacs and Linddeman in 1957. It referred to a factor that could cause inhibition in the growth of the live influenza virus. Interferons are intracellular proteins that are involved in many cellular processes such as growth, proliferation, differentiation, metabolism of the extracellular matrix, apoptosis, and regulating immune responses. T...
Objective: Although type 2 diabetes is a multifactorial illness, one of the major risk factors is the prevalence of obesity.In this context, recent genetic studies on diabetics or pre-diabetics, have shown that some of the newly-known genes make the conditions for type 2 diabetes even in the absence of obesity. One of these genes is called mTORC1, which plays an important role in the synt...
Homeostasis of the epithelium is depend-ent on Wnt/beta-catenin pathway, which regulates proliferation intestinal stem cells. The gain function mutations in beta-catenin gene leads to rapid cell and malignant growth epithelium. In addition, maintenance these cells appears be linked mesenchymal-derived factors. Although communication between epithelial mesenchyme populations remains uncharacteri...
In this study, cell death regulation and induction in AML line from a relapsed MLL-rearranged model (MOLM-13) was investigated with doxorubin (Dox) betulinic acid (BetA), singly combination. CyQUANT Direct® Annexin V/propidium iodide double staining were used to measure the cytotoxic effects of compounds, respectively. Reactive oxygen species (ROS) generation measured using 2′,7′-dichlorofluore...
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