objective(s):solanum acueastrum dunal.has been shown to have some chemotherapeutic value. leaf and berry water and methanol compounds of s. acueastrum were evaluated for possible antileishmanial activity in vivo on balb/c mice and in vitro against leishmania major promastigotes, amastigotes and vero cells.  materials and methods: dry s. aculeastrum berry and leaf material were extracted in meth...

In contrast to intact BALB/c mice, BALB/c mice rendered deficient in Vbeta4+ CD4+ T cells develop a Th1 response to infection with Leishmania major and are resistant. Vbeta4-deficient BALB/c mice are unable to generate the early IL-4 transcription occurring in Vbeta4 Valpha8 CD4+ T cells of BALB/c mice within 1 day of infection. Here we demonstrate that treatment of Vbeta4-deficient BALB/c mice...

Intravenous inoculation ofBCG was found to be both prophylactic and therapeutic in BALB/c mice against challenge with amastigotes of Leishmania donovani. Spleens and livers of mice inoculated with BCG maintained total parasite burdens at significantly lower levels when compared to controls. BCG administered intravenously 14 days prior to and on the same day of protozoan challenge was more prote...

wnloade ention of breast cancer can be achieved with a better understanding of the factors contributing to l breast development. Because the breast develops postnatally, alterations in the development and e activity of the neuroendocrine system may set up an environment that increases cancer risk. The t study examined how two neonatal experiences over the first 3 weeks of life influence normal ...

background pomegranate (punica granatum) is a significant source of bioactive compounds. however, its toxicity is not intensively studied. objectives the current study investigated the safety and tolerability of pomegranate peel extract (ppe) in balb/c mice. conclusions the current study showed that ppe had no toxicity and its use is suggested with potential applications against diseases. resul...

Characteristics of the acquisition processes of discrete lever-press and shuttle avoidance responses (intertrial interval = 25 sec, warning duration = 5 sec with an escape contingency, and 1 session = 1 hr training/day) as well as those of the ambulatory activity were investigated in 6 strains of mice (dd, ICR, BALB/c, C57BL/6, C3H/He and DBA/2). In the lever-press avoidance situation, the dd, ...

From a panel of nine inbred mice strains intranasally infected with Streptococcus pneumoniae type 2 strain, BALB/c mice were resistant and CBA/Ca and SJL mice were susceptible to infection. Further investigation revealed that BALB/c mice were able to prevent proliferation of pneumococci in the lungs and blood, whereas CBA/Ca mice showed no bacterial clearance. Rapidly increasing numbers of bact...

Pseudomonas aeruginosa (Pa) is an opportunistic pathogen that threatens the health, especially in immunocompromised individuals. survives everywhere, including a shuttle of spaceflights. Survival and starvation Pa water probably increase or decrease degree pathogenicity virulence, but it not well discovered. To promote our understanding mechanisms long-term survival water, investigations on kin...