The scope of this study was to determine the eff ect of gemfibrozil, l-carnitine and their combination on paraoxonase/arylesterase activity, oxidative/ anti-oxidative parameters and hepatosteatosis in rabbits on fat-rich diet. The study involved 35 New Zealand albino white rabbits. Animals were equally divided into 5 groups (n=7); group I: control (standard diet), group II: rabbits received onl...

OBJECTIVE Oxidative stress is the main pathogenetic mechanism in bladder cancer among many other causes. We aimed to investigate whether a potential relationship exists between bladder cancer and the activities of paraoxonase (PON1) and arylesterase (ARE) enzymes. MATERIAL AND METHODS The study included 56 patients with bladder cancer, and 57 healthy individuals. The relationships between enz...

One hundred and seventy-one genes encoding potential esterases from 11 bacterial genomes were cloned and overexpressed in Escherichia coli; 74 of the clones produced soluble proteins. All 74 soluble proteins were purified and screened for esterase activity; 36 proteins showed carboxyl esterase activity on short-chain esters, 17 demonstrated arylesterase activity, while 38 proteins did not exhib...

background: many studies have investigated the possible role of reactive oxygen species in the etiology and patho­gene­sis of rheumatoid arthritis (ra). the aim of this study was to investigate the activities of some antioxidants in ra patients. methods: in this case-control study, 59 ra patients and 60 healthy sex and age-matched controls were selected. vitamin e and beta-carotene were determi...

Cardiac death from atherosclerosis is common in hemodialysis patients. Human serum paraoxonase (PON1), an esterase, is associated with high-density lipoprotein and inhibits the susceptibility to oxidization of low-density lipoprotein (LDL). The PON1 genetic polymorphisms of 192 Gln/Arg and 55 Leu/Met in the amino acid sequence are partly involved in the PON1 enzyme activity. We investigated the...

In serum, human paraoxonase/arylesterase (PON1) is found exclusively associated with high density lipoprotein (HDL) and contributes to its antiatherogenic properties by inhibiting low density lipoprotein (LDL) oxidation. Difficulties in purifying PON1 from apolipoprotein A-I (apoA-I) suggested that PON1's association with HDL may occur through a direct binding between these 2 proteins. An unusu...

INTRODUCTION Laparoscopic cholecystectomy is the gold standard for the treatment of gallstone disease; however, adverse hemodynamic changes induced by increased intraabdominal pressure due to pneumoperitoneum are known to occur. Herein, we investigated the effects of pneumoperitoneum on oxidative stress markers, including paraoxonase, arylesterase, total oxidant status, and total antioxidant st...

Background: Coronary artery disease (CAD) is one of the leading causes death worldwide. Clopidogrel, antiplatelet drug, has been widely used for management CAD. Arylesterase, activity Paraoxonase-1 (PON-1), mainly contributed in biotransformation clopidogrel to its active thiol form. The purpose this study was investigate effect receiving drug on arylesterase activities CAD patients. antioxidan...

Paraoxonase-1, a high-density lipoprotein linked enzyme complex, was shown to be decreased in several cardiovascular diseases. We aimed to explore whether serum paraoxonase and arylesterase activities differ in dipper and non-dipper prehypertensive subjects compared to healthy controls.Sixty prehypertensive subjects and 30 controls were enrolled. All subjects underwent echocardiographic assessm...