Freshly isolated human leukemia cells have been shown in the past to display varying in vitro responses to phorbol diesters, depending on their cell type. Specific receptors for the phorbol diesters have been demonstrated on numerous different cells. This study was designed to characterize the receptors for phorbol diesters on leukemia cells freshly isolated from patients with different kinds o...

Acute Myeloid Leukemia Articles and Brief Reports haematologica | 2012; 97(2) 227

A 44-year-old quadriplegic woman presented with fevers, hematuria, and a leukemoid reaction of >70,000 cells/mL. Workup for infectious etiologies was negative. A large bladder mass with bilateral lymphadenopathy was discovered by pelvic CT with biopsy revealing a dedifferentiated urothelioma. The cancer was deemed inoperable. The patient was subsequently found to have an elevated GCSF of 182.9 ...

In his Pulitzer Prize winning novel “The Emperor of all Maladies”, Dr. Siddhartha Mukherjee eloquently summarizes the history of rational drug design and its origins in understanding the impact of a foodderived bioactive compound (i.e., folic acid) in disease pathophysiology. Dr. Mukherjee reminds us that Sidney Farber’s 1948 seminal paper[1] in the New England Journal of Medicine set the frame...

Through the isolation of suppressors of temperature-sensitive flagellar assembly mutations at the FLAlO locus of Chlamydomonas reinhardtii, we have identified six other genes involved in flagellar assembly. Mutations at these suppressor loci, termed SUFI-SUF6, display allele specificity with respect to which jZalOmutant alleles they suppress. An additional mutation, apml-122, which confers resi...

Kuwata et al’s recent article1 reports that vitamin A deficiency in mice causes a systemic expansion of myeloid cells. Based on their findings, the authors conclude that retinoids critically control the homeostasis of myeloid cell population in vivo and suggest that retinoid status may have an important role in the pathogenesis of various myeloproliferative disorders (MPDs). How valid is this s...

Kuwata et al’s recent article1 reports that vitamin A deficiency in mice causes a systemic expansion of myeloid cells. Based on their findings, the authors conclude that retinoids critically control the homeostasis of myeloid cell population in vivo and suggest that retinoid status may have an important role in the pathogenesis of various myeloproliferative disorders (MPDs). How valid is this s...

This paper suggests a syntax for an XML-based language for representing and annotating emotions in technological contexts. In contrast to existing markup languages, where emotion is often represented in an ad-hoc way as part of a specific language, we propose a language aiming to be usable in a wide range of use cases, including corpus annotation as well as systems capable of recognising or gen...