Second-generation antihistamines are widely prescribed for the control of symptoms of allergic inflammation such as itchy hives, coryza, and itchy eyes. In rare circumstances, these drugs might provoke allergic inflammation. Hypersensitivity to bepotastine besilate, a second-generation antihistamine has never been reported. A 17-year-old schoolgirl, whose paroxysmal itchy hives had been control...

Treatment for allergic conjunctivitis has markedly expanded in recent years, providing opportunities for more focused therapy, but often leaving both physicians and patients confused over the variety of options. As monotherapy, oral antihistamines are an excellent choice when attempting to control multiple early-phase, and some late-phase, allergic symptoms in the eyes, nose and pharynx. Unfort...

H1-antihistamines are widely used for the treatment of allergic disorders, both systemically and topically. Topically, they are used on the skin for general itch relief, and in the eye or nose for mucosal complaints. Hypersensitivity to topical antihistamines is often not suspected, because of their use as ‘anti-allergic medications’. There are a few reports describing hypersensitivity to topic...

P INTRODUCTION A symposium organized by National Jewish Health and held in Denver, Colorado, on October 8, 2009, investigated the role of intranasal antihistamines for allergic rhinitis. It was titled Rethinking the Treatment of Allergic Rhinitis; the Role of Intranasal Antihistamines: “Me Too Drugs” or a Novel Class? Articles 1 through 4 in this supplement provide detailed information about th...

BACKGROUND Chronic spontaneous urticaria is a debilitating disease for the patients and often considered by the doctors a very difficult disease to treat. In 2009 the European Academy of Allergy and Clinical Immunology/Global Allergy and Asthma European network/European Dermatology Forum/World Allergy Organization (EAACI/GA(2)LEN/EDF/WAO) published a revised version of the guidelines for the tr...

Allergic rhinitis is the mostprevalent chronic allergic disease in children. Although it is not life-threatening, it can have a significantly detrimental effect on a childs quality of life, and it may exacerbate a number of common comorbidities, including asthma and sinusitis. The Allergic Rhinitis and its Impact on Asthma guidelines, an evidence-based algorithm for the treatment of allergic rh...