The management of HIV-exposed and HIV-infected children has been improved by the introduction of new testing methods and of new antiretroviral agents. Whenever practical, such children should be cared for in consultation with paediatric infectious disease physicians with HIV expertise. Physicians caring for these children should refer to the United States National Institutes of Health guideline...

INTRODUCTION New antiretroviral agents that are more convenient, better tolerated with fewer short- and long-term side effects, and that have novel resistance patterns are needed at all lines of therapy in patients infected with human immunodeficiency virus (HIV). Therefore, next generation products of current classes and alternative classes of antiretroviral agents are needed. The CC-chemokine...

Since the introduction of the first antiretroviral drug, zidovudine, in 1987, over 25 different antiretroviral agents from six different drug classes have been approved for the treatment of HIV-1 infection. Today, combination antiretroviral therapy (ART) is extremely effective in suppressing HIV-1 replication, providing durable control of the virus in adherent patients. However, despite the eff...

70 Many advances have been made in understanding the pathogenesis and progression of HIV disease, developing effective antiretroviral agents and regimens, learning how best to use these regimens for prolonged maximal viral suppression, lowering the pill burden of regimens, and managing many acute adverse effects of treatment. The problems for many patients on long-term effective antiretroviral ...

INTRODUCTION We assessed trends in HIV Care Continuum outcomes associated with delayed disease progression and reduced transmission within a large Latin American cohort over a decade: clinical retention, combination antiretroviral therapy (cART) use and viral suppression (VS). METHODS Adults from Caribbean, Central and South America network for HIV epidemiology clinical cohorts in seven count...

The study objective was to evaluate the pharmacodynamics of amprenavir in an in vitro system, develop an exposure target for maximal viral suppression, and determine the likelihood of target attainment based on the pharmacokinetics of amprenavir and ritonavir in human immunodeficiency virus (HIV)-infected patients. Population pharmacokinetic data were obtained from 13 HIV-infected patients rece...

Adherence to Protease Inhibitors TO THE EDITOR: In an excellent paper, Paterson and colleagues (1) demonstrate that adherence to protease inhibitor therapy of 95% or greater optimizes virologic outcome for patients with HIV infection. In our opinion, however, this conclusion cannot be generalized to all HIV-infected patients, especially those who were previously treated with antiretroviral agen...

Members of the Working Group on Antiretroviral Therapy and Medical Management of HIV-Infected Children have developed this Pediatric Antiretroviral Drug Information Supplement. As new information becomes available, the supplement will be updated. This document contains detailed information about the different classes of antiretroviral agents, and should be used in conjunction with the Guideline...

peperomia pellucida leaf extract was characterized for its anticancer, antimicrobial, antioxidant activities, and chemical compositions. anticancer activity of p. pellucida leaf extract was determined through colorimetric mtt (tetrazolium) assay against human breast adenocarcinoma (mcf-7) cell line and the antimicrobial property of the plant extract was revealed by using two-fold broth micro-di...