Papillary muscle infarction was produced in 16 mongrel dogs by placing sutures around the base of one of the papillary muscles. In addition, patchy infarction of the adjacent left ventricular wall was produced by placing an Ameroid constrictor around the appropriate coronary artery. Mitral insufficiency developed in 14 of these animals; it was severe in four and mild to moderate in ten. Mitral ...

Background The mitral apparatus contains two myocardial components papillary muscles and the adjacent left ventricular (LV) wall. Delayed enhancement CMR (DE-CMR) enables in-vivo study of potential contributions of LV wall and papillary muscle infarction (PMI) to MR. This study examined the relative impact of papillary muscle and LV wall infarction on mitral regurgitation (MR) following ST elev...

BACKGROUND The effects of aging on papillary muscle have been widely demonstrated, but no data on the effects of exercise on the age-related changes are available. OBJECTIVE To analyze the effects of aging on the morphological and quantitative properties of papillary muscle and investigate whether a long-term moderate exercise program would exert a protective effect against the effects of agi...

A 64-year-old Japanese man was referred to our hospital because of palpitation. An electrocardiogram revealed firstdegree atrioventricular block without ST-T change. An echocardiography showed structural abnormality into the left ventricular outflow tract (LVOT), mitral valve leaflet cleft without mitral regurgitation, and single papillary muscle (loss of posterior papillary muscle) (Figs. 1, 2...

Papillary muscle isolated from adult mouse hearts can be used to study cardiac contractility during different physiological/pathological conditions. The contractile characteristics can be evaluated independently of external influences such as vascular tonus or neurohumoral status. It depicts a scientific approach between single cell measurements with isolated cardiac myocytes and in vivo studie...

Introduction Papillary muscle involvement in acute myocardial infarction (MI) may be associated with new-onset mitral regurgitation and ventricular arrhythmias. Late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) imaging can detect and quantify myocardial scar. The detection of papillary muscle involvement however may be challenged by difficulties discriminating the affect...

OBJECTIVE One of the mechanisms of development of functional mitral regurgitation after myocardial infarction is the increased papillary muscle distance which results due to ventricle remodeling. The aim of this study was to investigate the long-term effect of papillary muscle approximation (PMA) on the cardiac function of patients with ischemic cardiomyopathy and increased papillary muscle dis...